结肠肝样腺癌1例

Hepatoid adenocarcinoma of colon: A case report

肝样腺癌是一种罕见的腺癌组织病理学亚型,相对常见于胃,少见于肠道。海军军医大学长海医院收治了1例44岁男性乙状结肠原发性肝样腺癌病例。肿瘤组织主要呈梁索状、巢片状排列,细胞呈大多角形,细胞质丰富嗜酸性,核大深染,异型明显。免疫组织化学示AFP、Arginase-1、Glypican-3、CDX-2阳性,不表达CgA、Syn。患者手术后预后不佳。结肠肝样腺癌是一种独特的肠腺癌亚型,诊断高度依赖于病理,生物学行为恶性程度高,需予以重视。

Hepatoid adenocarcinoma is a peculiar histopathological subtype of adenocarcinoma,which occurs commonly in the stomach and rarely in the intestine.A 44-year-old male patient with primary hepatoid adenocarcinoma located at the sigmoid colon was admitted to Changhai Hospital of Naval Medical University.The tumor tissue was mainly arranged in the shape of beam cord and nest,with large polygonal cells,abundant eosinophilic cytoplasm,large and hyperchromatic nuclei,and obvious atypia.AFP,Arginase-1,Glypican-3,and CDX-2 were positive,but CgA and Syn were negative by immunohistochemistry.The patient’s prognosis after surgery was poor.Hepatoid adenocarcinoma of the colon is an independent subtype of adenocarcinoma of the intestine.The diagnosis is highly dependent on pathology,with high malignancy in biological behavior,which should be paid more attention to.