高分辨CT联合CEA诊断恶性肺部结节的效果

High-resolution CT combined with CEA in the diagnosis of benign and malignant pulmonary nodules

目的 探究高分辨CT(HRCT)联合血清癌胚抗原(CEA)诊断恶性肺部结节的效果。方法 采用回顾性分析的方法,选取2019年4月至2020年7月于本院就诊后发现孤立性肺结节(SPN)的92例患者作为研究对象。以术后病理结果为金标准,将患者分为良性组(29例)和恶性组(63例)。患者均接受HRCT及CEA检查,以SPN为状态变量绘制患者的工作特性曲线(ROC),并通过ROC分析HRCT及CEA对SPN的诊断效能。结果 良性组HRCT征象中分叶征、毛刺征发生率低于恶性组(P<0.05);良性组血清CEA水平低于恶性组(P<0.05);HRCT及CEA联合诊断恶性SPN的ROC曲线面积(AUC)为0.800,敏感度84.13%、特异度82.75%。结论 高分辨CT联合CEA诊断恶性肺部结节具有较高灵敏度和特异度。

Objective To explore the effect of high resolution CT(HRCT)combined with serum carcinoembryonic antigen(CEA)in the diagnosis of benign and malignant pulmonary nodules.Methods Using retrospective analysis, 92 patients with solitary pulmonary nodules(SPN)found in our hospital from April 2019 to July 2020 were selected as the research objects.Taking postoperative pathological results as the gold standard, patients were divided into benign group(29 cases)and malignant group(63 cases).All patients were diagnosed by HRCT and CEA,and SPN was used as the state variable to draw the patient′s operating characteristic curve(ROC),and the diagnostic efficacy of HRCT and CEA for SPN was analyzed through ROC.Results The incidence of lobular sign and burr sign in the HRCT signs of the benign group was lower than that of the malignant group(P<0.05),the serum CEA level of the benign group was lower than that of the malignant group(P<0.05),the maximum ROC curve area(AUC)of combined diagnosis was 0.800.The sensitivity is 84.13% and the specificity is 82.75%.Conclusion High-resolution ct combined with CEA to diagnose benign and malignant pulmonary nodules can effectively improve the diagnostic accuracy of benign and malignant pulmonary nodules.