常规对症治疗基础上加用rhIFN-α1b雾化吸入治疗小儿毛细支气管炎的疗效机制

Efficacy and mechanism of rhIFN-α1b inhalation in the treatment of children with bronchiolitis on the basis of conventional symptomatic treatment

目的:研究毛细支气管炎患儿在常规对症治疗的基础上加用重组人干扰素(rhIFN)-α1b雾化吸入的临床疗效。方法:102例研究对象均选自我院2019年1月~2021年12月收治的毛细支气管炎患儿,以随机数字表法将其分为观察组和对照组,均51例。对照组患儿接受常规对症治疗,观察组患儿则在此基础上加用rhIFN-α1b雾化治疗。两组患儿均持续治疗1周。比较两组患儿临床症状消失时间,治疗后临床疗效,治疗前后肺功能指标,血清细胞间黏附分子(ICAM)-1、半胱氨酰白三烯(CysLTs)、白细胞介素(IL)-18、IL-33、嗜酸粒细胞阳离子蛋白(ECP)、嗜酸性粒细胞(EOS)、呼出气一氧化氮(FeNO)水平。结果:治疗后,观察组总有效率高于对照组;观察组啰音消失时间、咳嗽消失时间、憋喘消失时间、发热消退时间、三凹征消失时间均短于对照组;与治疗前比,治疗后两组PTEF、VT、TPTEF/TE水平均升高,其中观察组高于对照组;Rrs、血清ICAM-1、CysLTs、IL-18、IL-33、ECP、EOS、FeNO水平均降低,其中观察组低于对照组。结论:毛细支气管炎患儿在常规对症治疗的基础上加用rhIFN-α1b雾化吸入能够有效减轻炎症反应,改善肺功能,加速临床症状消退,且疗效更佳。

Objective To study the clinical efficacy of inhalation of recombinant human interferon (rhIFN)-α1b on the basis of routine symptomatic treatment in children with bronchiolitis.Methods A total of 102 research subjects were selected from children with bronchiolitis who were treated in our hospital from January 2019 to December 2021.They were divided into an observation group and a control group by random number table method,with 51 cases in each.The children in the control group received conventional symptomatic treatment,while the children in the observation group received rhIFN-α1b atomization treatment on this basis.Both groups were treated continuously for 1 week.The disappearance time of clinical symptoms,clinical efficacy after treatment,pulmonary function indexes,serum intercellular adhesion molecule (ICAM)-1,cysteinyl leukotrienes (CysLTs),interleukin (IL-18).IL-33,eosinophil cationic protein (ECP),eosinophil (EOS),fractional exhaled nitric oxide (FeNO) levels before and after treatment were compared.Results After treatment,the total effective rate of the observation group was higher than that of the control group;The disappearance time of rales,cough disappearance,wheezing,fever and three concave signs in the observation group were shorter than those in the control group;Compared with before treatment,the levels of PTEF,VT and TPTEF/TE in the two groups increased after treatment,and the observation group was higher than the control group;The levels of Rrs,serum ICAM-1,CysLTs,IL-18,IL-33,ECP,EOS,and FeNO decreased,and the observation group was lower than the control group.Conclusion In children with bronchiolitis,the addition of rhIFN-α1b aerosol inhalation on the basis of conventional symptomatic treatment can effectively reduce the inflammatory response,improve the lung function,accelerate the clinical symptom regression,and the curative effect is better.