冠状动脉静息全周期比值研究进展

Research progress of coronary resting full-cycle ratio

冠心病的诊治已经进入功能学检查的新时代,血流储备分数(FFR)作为冠状动脉(冠脉)功能学检查的“金标准”,可以指导冠脉介入治疗的决策,并改善预后。然而,由于检查中需要使用扩血管药物使血管扩张,由此带来的不良反应使得FFR在临床应用中受到限制。静息全周期比值(RFR)是一种新的冠脉功能学检测方法,定义为全心动周期内冠脉远端压力与近端主动脉压力之比的最小值。RFR在检测中无需使用扩血管药物,从而避免了相关不良反应,在冠脉介入治疗的术前评估和心肌桥评估等方面也取得了一定的成果,有望替代FFR应用于临床中。本文将对RFR现有的临床研究进行综述。

The diagnosis and treatment of coronary heart disease has entered a new era of functional examination.Fractional flow reserve(FFR),as the"gold standard"of coronary artery functional examination,can guide the coronary intervention and improve the prognosis.However,due to the need to use vasodilators to dilate blood vessels during the examination,the adverse reactions have limited the clinical application of FFR.Resting-to-full-cycle ratio(RFR)is a novel measure of coronary function defined as the minimum value of the ratio of distal coronary pressure to proximal aortic pressure over a full cardiac cycle.RFR does not need to use vasodilators,thus avoiding related adverse reactions,and has also achieved certain results in the preoperative evaluation of coronary intervention and myocardial bridge evaluation.It is expected to replace FFR in clinical application.This article will review the existing clinical studies of RFR.