谷红注射液联合阿替普酶治疗急性脑梗死患者的血清相关因子水平变化探讨

Changes of Serum Related Factors in Patients with Acute Cerebral Infarc⁃tion Treated with Guhong Injection Combined with Alteplase

目的探讨急性脑梗死治疗中阿替普酶联合谷红注射液用药前后患者的血清相关因子水平变化。方法回顾性选取2020年2月—2021年2月赤峰市医院收治的急性脑梗死患者100例。依据用药方法分为联合用药组(阿替普酶联合谷红注射液用药)、单独用药组(阿替普酶单独用药)两组,各50例。统计分析两组患者的神经功能缺损程度、血清炎性因子水平、血清纤溶系统因子水平、血管内皮功能、临床疗效。结果用药后,联合用药组患者的NIHSS评分、血清IL-6、IL-8、IL-10、TNF-α、hs-CRP水平均低于单独用药组,差异有统计学意义(P<0.05)。用药后,联合用药组患者的血清PAI-1、P-selectin、vWF水平均低于单独用药组,血清t-PA水平高于单独用药组,差异有统计学意义(P<0.05)。用药后,联合用药组患者的血清VEGF、BDNF水平均高于单独用药组,血清ET-1、H-FABP、PAO、CEC、S100-β、Fibulin-5水平均低于单独用药组,差异有统计学意义(P<0.05)。联合用药组患者治疗的总有效率98.00%(49/50)高于单独治疗组82.00%(41/50),差异有统计学意义(χ^(2)=7.111,P<0.05)。结论急性脑梗死治疗中阿替普酶联合谷红注射液用药较阿替普酶单独用药更能有效改善患者的血清相关因子水平。

Objective To investigate the changes of serum related factors in patients with acute cerebral infarction before and after administration of alteplase combined with Guhong injection.Methods A total of 100 patients with acute cerebral infarction admitted to Chifeng City Hospital from February 2020 to February 2021 were retrospectively selected.According to the method of medication,they were divided into a combined medication group(alteplase combined with Guhong injection)and a single medication group(alteplase alone),with 50 cases in each group.The degree of neurological deficit,serum inflammatory factor levels,serum fibrinolytic system factor levels,vascular endothelial function,and clinical efficacy of the two groups of patients were statistically analyzed.Results After treatment,the NIHSS score,serum IL-6,IL-8,IL-10,TNF-α,and hs-CRP levels in the combined treatment group were lower than those in the single treatment group,and the difference was statistically significant(P<0.05).After treatment,the serum levels of PAI-1,P-selectin and vWF in the combined treatment group were lower than those in the single treatment group,and the serum t-PA level was higher than that in the single treatment group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum VEGF and BDNF in the combined treatment group were higher than those in the single treatment group,and the levels of serum ET-1,H-FABP,PAO,CEC,S100-βand Fibulin-5 were lower than those in the single treatment group,and the difference was statistically significant(P<0.05).The total effective rate of patients in the combination group was 98.00%(49/50)higher than that in the single treatment group,82.00%(41/50),and the difference was statistically significant(χ^(2)=7.111,P<0.05).Conclusion In the treatment of acute cerebral infarction,alteplase combined with Guhong injection can effectively improve the serum related factor levels of patients compared with alteplase alone.