米非司酮治疗人工流产术后宫腔残留物的效果及有效率影响分析

Effect of Mifepristone in the Treatment of Uterine Cavity Residues after In⁃duced Abortion and the Effect of Effective Rate

目的探讨人工流产术后存在宫腔残留物的患者应用非米司酮展开治疗的效果。方法选取2019年6月—2021年6月山东省青岛市莱西市人民医院收治的人工流产术后存在宫腔残留物的患者80例。采用数字表抽取法分组,对照组40例应用二次清宫方案治疗,观察组40例采用米非司酮治疗。对比两组总有效率、阴道持续出血时长、月经复潮时间、血β-HCG下降值、并发症发生率。结果观察组总有效率97.50%高于对照组72.50%,差异有统计学意义(χ^(2)=9.804,P<0.05)。观察组阴道持续出血时长、月经复潮时间分别为(4.55±1.02)、(25.12±1.09)d,短于对照组的(6.89±1.07)、(32.15±2.20)d,差异有统计学意义(t=10.011、18.109,P<0.05)。治疗2、4周后,观察组血β-HCG下降值分别为(204.23±11.39)、(207.45±13.81)mIU/mL,高于对照组的(160.81±10.42)、(199.81±13.62)mIU/mL,差异有统计学意义(t=17.789、2.491,P<0.05)。观察组头晕、恶心、月经失调、感染并发症发生率为5.00%,低于对照组的20.00%,差异有统计学意义(χ^(2)=4.114,P<0.05)。结论针对人工流产术后存在宫腔残留的患者,采用米非司酮展开治疗与二次清宫术进行比较,总有效率居更高水平,可缩短阴道持续出血时长,促进月经复潮,降低血β-HCG下降值,且具更高安全性。

Objective To investigate the effect of mispristone in the treatment of patients with uterine remnants after induced abortion.Methods A total of 80 patients with residual uterine cavity after induced abortion who were admitted to Laixi People′s Hospital,Qingdao,Shandong Province from June 2019 to June 2021 were selected.The digital table extraction method was used for grouping,40 cases in the control group were treated with the second palace cleaning regimen,and 40 cases in the observation group were treated with mifepristone.The total effective rate,duration of vaginal bleeding,time of menstrual rehydration,bloodβ-HCG decline,and incidence of complications were compared between the two groups.Results The total effective rate of the observation group was 97.50%higher than that of the control group 72.50%,and the difference was statistically significant(χ^(2)=9.804,P<0.05).The duration of vaginal bleeding and the time of menstrual rehydration in the observation group were(4.55±1.02)d,(25.12±1.09)d shorter than those in the control group(6.89±1.07)d and(32.15±2.20)d,respectively,and the differences were statistically significant(t=10.011,18.109,P<0.05).2 weeks and 4 weeks after treatment,the bloodβ-HCG decreased values in the observation group were(204.23±11.39)mIU/mL,(207.45±13.81)mIU/mL higher than those in the control group(160.81±10.42)mIU/mL,(199.81±13.62)mIU/mL,the difference was statistically significant(t=17.789,2.491,P<0.05).The incidence of complications of dizziness,nausea,menstrual disorders,and infection in the observation group was 5.00%lower than that in the control group,which was 20.00%,and the difference was statistically significant(χ^(2)=4.114,P<0.05).Conclusion For patients with residual uterine cavity after induced abortion,the total effective rate of mifepristone compared with the second uterine evacuation is higher,which can shorten the duration of continuous vaginal bleeding,promote menstrual rejuvenation,reduce the decline of bloodβ-HCG,and has higher safety.