丹参酮联合曲安奈德治疗口腔黏膜下纤维性变及对纤维蛋白原水平影响分析

Tanshinone Combined with Triamcinolone Acetonide in the Treatment of Oral Submucosal Fibrosis and Its Effect on Fibrinogen Levels

目的评估丹参酮+曲安奈德对口腔黏膜下纤维性变(oral submucosal fibrosis,OSF)患者的效果及对纤维蛋白原(FIB)水平的影响。方法选取2020年2月—2021年4月荆门市京山仁和医院收治的86例OSF患者为研究对象,按照随机方式分为观察组(43例,行丹参酮+曲安奈德治疗)和对照组(43例,行曲安奈德治疗),比较两组血清生化指标、中医证候积分、血液流变学、张口度、视觉模拟评分法(VAS)、黏膜病损面积、用药不良反应、临床有效率。结果治疗前,两组血清生化指标、中医证候积分、血液流变学、张口度、VAS、黏膜病损面积比较,差异无统计学意义(P>0.05);治疗后,观察组血清生化指标、中医证候积分、血液流变学、张口度、VAS、黏膜病损面积均优于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率(9.30%)与对照组(11.63%)比较,差异无统计学意义(P>0.05);观察组临床有效率(97.67%)高于对照组(81.39%),差异有统计学意义(χ^(2)=4.468,P<0.05)。结论对OSF患者行丹参酮+曲安奈德治疗,能够增强疗效、改善血清生化指标及血液流变学、降低疼痛程度、减少黏膜病损面积、不增加不良反应。

Objective To evaluate the effect of tanshinone+triamcinolone acetonide on oral submucosal fibrosis(OSF)patients and the effect on fibrinogen(FIB)level.Methods 86 OSF patients admitted to Jingshan Renhe Hospital from February 2020 to April 2021 were included as the research objects and were divided into to the observation group(43 cases,treated with tanshinone+triamcinolone acetonide)and the control group(43 cases,treated with triamcinolone acetonide).Serum biochemical indexes,TCM syndrome scores,hemorheology,mouth opening,visual analogue scale(VAS),mucosal lesion area,adverse drug reactions and clinical efficacy were evaluated between groups.Results Before treatment,there were no statistically significant differences in serum biochemical indexes,TCM syndrome scores,hemorheology,mouth opening,VAS,and mucosal lesion area between the two groups(P>0.05).After treatment,serum biochemical indexes,TCM syndrome scores,hemorheology,mouth opening,VAS and mucosal lesion area in the observation group were better than the control group,the difference was statistically significant(P<0.05).In terms of adverse drug reactions,there was no statistically significant difference in the incidence of adverse drug reactions between the observation group(9.30%)and the control group(11.63%)(P>0.05).The clinical efficacy in the observation group(97.67%)was higher than the control group(81.39%),and the difference was statistically significant(χ^(2)=4.468,P<0.05).Conclusion Tanshinone+triamcinolone acetonide treatment for OSF patients can enhance the curative effect,improve serum biochemical indexes and hemorheology,reduce the degree of pain,reduce the area of mucosal lesions,and less adverse reactions.