采用头孢曲松钠注射液、多西环素片和甲硝唑片治疗盆腔炎患者的临床疗效和安全性

Clinical Efficacy and Safety of Ceftriaxone sodium Injection,Doxycycline Tablets and Metronidazole Tablets in the Treatment of Patients with Pel⁃vic Inflammatory Disease

目的对3种药物(头孢曲松钠注射液、多西环素片、甲硝唑片)联合在盆腔炎疾病治疗中的临床运用效果及安全性进行观察与探究。方法将日照市妇幼保健院2019年3月—2021年2月所接诊的98例盆腔炎患者作为研究对象,按随机数表法分为甲组与乙组,各49例。前一组采取头孢曲松钠注射液+多西环素片治疗,在此基础之上,后一组再予以甲硝唑片治疗。比较两组患者的治疗总有效率、治疗前后CPR、GM-CSF、MCP-1指标变化以及不良反应发生率等情况。结果乙组患者治疗后的总有效率(93.88%)明显比甲组(79.59%)高,差异有统计学意义(χ^(2)=4.346,P<0.05)。两组治疗前的CPR、GM-CSF、MCP-1指标相比较,差异无统计学意义(P>0.05);治疗后,两组CPR、GM-CSF、MCP-1指标低于本组治疗前,差异有统计学意义(P<0.05);乙组CPR、GM-CSF、MCP-1指标显著低于甲组,差异有统计学意义(P<0.05)。在不良反应方面,甲、乙两组患者的发生率(14.29%vs 8.16%)相比较,差异无统计学意义(χ^(2)=0.922,P>0.05)。结论对盆腔炎患者采取头孢曲松钠注射液、多西环素片、甲硝唑片3种药物联合治疗,效果甚佳,不但能有效控制血清中CPR、GM-CSF、MCP-1各指标的浓度,且不良反应发生率低,安全性高。

Objective To observe and explore the clinical efficacy and safety of the combination of three drugs(ceftriaxone sodium injection,doxycycline tablets,metronidazole tablets)in the treatment of pelvic inflammatory disease.Methods Ninety-eight patients with pelvic inflammatory disease admitted to Rizhao Maternal and Child Health Hospital from March 2019 to February 2021 were selected as study objects.According to the random number table method,they were divided into group A and group B(49 cases in each).The former group was treated with ceftriaxone sodium injection+doxycycline tablets,and on this basis,the latter group was treated with metronidazole tablets.The total effective rate of treatment,the changes of CPR,GM-CSF,MCP-1 indexes and the incidence of adverse reactions before and after treatment in the above two groups were compared.Results The total effective rate(93.88%)of group B patients after treatment was significantly higher than that of group A patients(79.59%),and the difference was statistically significant(χ^(2)=4.346,P<0.05).There was no statistically significant difference in CPR,GM-CSF and MCP-1 between the two groups before treatment(P>0.05).After treatment,the indexes of CPR,GM-CSF and MCP-1 in the two groups were lower than those before treatment in the same group,and the difference was statistically significant(P<0.05);the CPR,GM-CSF and MCP-1 indexes of group B after treatment were significantly lower than those of group A,and the difference was statistically significant(P<0.05).In terms of adverse reactions,there was no statistically sig‐nificant difference in the incidence rates of patients in the two groups(14.29%vs 8.16%)(χ^(2)=0.922,P>0.05).Con⁃clusion The three-drug combination therapy of ceftriaxone injection,doxycycline tablets and metronidazole tablets for patients with pelvic inflammatory disease is very effective.It can not only effectively control the concentrations of CPR,GM-CSF and MCP-1 in serum,but also has a low incidence of adverse reactions and high safety.