西藏拉萨2型糖尿病患者合并高血压对血清白蛋白的影响

Effect of hypertension on the level of serum albumin in Lhasa type-2 diabetic patients

目的:分析西藏拉萨糖尿病患者合并高血压对血清白蛋白的影响。方法:采用回顾性的病例对照研究,纳入八廓街道常住居民中2型糖尿病患者149例。将76例糖尿病合并高血压患者归为病例组,73例糖尿病不合并高血压患者归为对照组。采用二元Logistic回归分析研究2型糖尿病合并高血压对血清白蛋白的影响。结果:2组患者的4个指标差异存在统计学意义,包括年龄(60.8±8.0岁vs 57.3±11.4岁,P<0.05)、平均收缩压(147±16mmHg vs 117±13mmHg,P<0.01)、平均舒张压(95±10mmHg vs 77±9mmHg,P<0.01)和平均血清白蛋白水平(27.7±7.4g/L vs 32.2±9.1g/L,P<0.01)。与不合并高血压的患者相比较,糖尿病合并高血压患者年龄相对较大,平均血清白蛋白水平较低。单因素分析结果显示,2个相关指标,包括年龄(OR值1.038,95%可信区间1.003~1.075,P=0.033)和血清白蛋白(OR值0.936,95%可信区间0.899~0.975,P=0.002)。多因素分析的结果显示,血清白蛋白是唯一相关指标(OR值0.938,95%可信区间0.900~0.978,P=0.002)。结论:西藏拉萨2型糖尿病合并高血压患者较不合并高血压的患者血清白蛋白水平降低。

Objective:To analyze the influence of hypertension on the level of serum albumin in Lhasa diabetic patients.Methods:We included 149 type-2 diabetic patients who were permanent residentsof Bakuo community.A retrospective case-control study was carried out for them,76 diabetic patients with hypertension served as the case group and the rest 73 without hypertension served as the control group.Chi-square test and independent sample T test were used to test the differences between the two groups.Binary logistic regression analysis was used to determine the influence of hypertension on the level of serum albumin,and the results were expressed as adjusted odds ratios(AOR)and their 95%confidence intervals(CI).Results:Compared with diabetic patients without hypertension,patients with hypertension had an older age(60.8±8.0y vs57.3±11.4y,P<0.05),increased levels of systolic blood pressure(147±16mmHg vs 117±13mmHg,P<0.01)and diastolic blood pressure(95±10mmHg vs 77±9mmHg,P<0.01),and a decreased level of serum albumin(27.7±7.4g/L vs 32.2±9.1g/L,P<0.01).Single factor analysis showed that statistical differences were found in age(OR=1.038,95%CI 1.003-1.075,P=0.033)and serum albumin(OR=0.936,95%CI 0.899-0.975,P=0.002).Multivariable analysis showed that after controlled the effect of the above variables,only serum albumin has significant difference(AOR=0.938,95%CI 0.900-0.978,P=0.002).Conclusion:The level of serum albumin was lower in Lhasa type-2 diabetic patients with hypertension compared with those without hypertension.