氯吡格雷联合依折麦布治疗冠心病心绞痛的疗效及对血清VEGF、NO、ET-1水平的影响研究

Efficacy of clopidogrel combined with ezetimibe in the treatment of coronary heart disease angina pectoris and its influence on serum VEGF,NO and ET-1 levels

目的探究氯吡格雷联合依折麦布治疗冠心病心绞痛的疗效及对血清血管内皮生长因子(VEGF)、一氧化氮(NO)、内皮素-1(ET-1)水平的影响。方法100例冠心病心绞痛患者,采用随机数字表法分为研究组和对照组,各50例。对照组患者采用氯吡格雷进行治疗,研究组采用氯吡格雷联合依折麦布进行治疗。比较两组患者临床疗效及治疗前后血清VEGF、NO、ET-1水平。结果研究组患者治疗总有效率96%明显高于对照组的74%,差异有统计学意义(P<0.05)。治疗后,两组患者血清VEGF、NO水平均明显高于本组治疗前,ET-1水平明显低于本组治疗前,且研究组患者血清VEGF(130.51±15.68)ng/L、NO(87.88±9.86)μmol/L均明显高于对照组的(108.66±12.71)ng/L、(76.28±8.91)μmol/L,ET-1(51.35±6.75)ng/L明显低于对照组的(61.23±7.53)ng/L,差异具有统计学意义(P<0.05)。结论氯吡格雷联合依折麦布治疗冠心病心绞痛疗效确切,对血管内皮细胞有保护作用,值得临床推广。

Objective To investigate the efficacy of clopidogrel combined with ezetimibe in the treatment of coronary heart disease angina pectoris and its influence on serum vascular endothelial growth factor(VEGF),nitric oxide(NO),and endothelin-1(ET-1)levels.Methods A total of 100 patients with coronary heart disease angina pectoris were randomly divided into research group and control group,with 50 cases in each group.The control group was treated with clopidogrel,and the research group was treated with clopidogrel combined with ezetimibe.The clinical efficacy and serum VEGF,NO and ET-1 levels before and after treatment were compared between the two groups.Results The total effective rate in the research group was 96%,which was significantly higher than 74%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum VEGF and NO in the two groups were significantly higher than those before treatment in this group,and the level of ET-1 was significantly lower than that before treatment in this group;the serum VEGF(130.51±15.68)ng/L and NO(87.88±9.86)μmol/L in the research group were significantly higher than(108.66±12.71)ng/L,(76.28±8.91)μmol/L in the control group;the ET-1(51.35±6.75)ng/L in the research group was significantly lower than(61.23±7.53)ng/L in the control group;the differences were all statistically significant(P<0.05).Conclusion Clopidogrel combined with ezetimibe is effective in the treatment of coronary heart disease angina pectoris and has a protective effect on vascular endothelial cells,which is worthy of clinical promotion.