艾滋病合并鸟-胞内分枝杆菌复合群中枢神经系统感染1例并文献复习

Central nervous system infection of AIDS complicated with Mycobacterium avian-intracellular complex: a case report and literature review

非结核分枝杆菌相关颅内感染相对罕见。本文报道了1例艾滋病合并鸟-胞内分枝杆菌复合群中枢系统感染病例。病例系1名45岁女性患者,因“头晕3月,加重伴头痛、失语1周”住院,入院后进行脑脊液检查,并利用二代宏基因组测序发现感染病原菌为鸟-胞内分枝杆菌复合群,从而采取相应的治疗措施,最终获得治愈。本文通过复习有关资料,深入探讨了艾滋病和非结核分枝杆菌相关性颅内感染的临床表现和处理,提示临床医生警惕非结核分枝杆菌相关性颅内感染及其严重性,及时确定病因并实施相应的干预措施。

Non-tuberculous Mycobacteria-related intracranial infections are relatively rare. The authors studied a case of AIDS complicated with central nervous system infection of Mycobacterium avian-intracellular complex. A 45-year-old female patient was hospitalized for “dizziness for 3 months, aggravation with headache and aphasia for 1 week”. Cerebrospinal fluid was tested after admission, and the pathogen of infection was found to be an avian-intracellular Mycobacterium complex by metagenomic Next-generation Sequencing(mNGS).The patient was cured after taking corresponding treatment measures.By reviewing relevant data, the authors discussed the clinical manifestations and management of AIDS and non-tuberculous Mycobacteria-related intracranial infections in-depth, and guided clinicians to be alert to the occurrence and severity of nontuberculous Mycobacteria-related intracranial infections, in order to determine the causes in time and implement corresponding intervention measures.