TG/HDL-C比值与2型糖尿病高危人群代谢综合征的相关性分析

Association of Triglyceride to High-Density Lipoprotein Cholesterol Ratio with Metabolic Syndrome in High-risk Diabetic Population

目的:探讨糖尿病高危人群中甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)与代谢综合征(Mets)的相关性。方法:根据《中国2型糖尿病防治指南(2017年版)》对2型糖尿病高危人群的定义,于2018年4月至2019年4月从河北省人民医院内分泌科门诊招募研究对象,共计531例参与了本研究。采用多因素Logistic回归模型评估TG/HDL-C与Mets之间的相关性。结果:患有Mets的人群TG/HDL-C显著高于无Mets者[1.73(1.03,2.55)vs 0.76(0.54,1.12),P<0.001]。随着TG/HDL-C的升高,Mets的患病率逐渐增加(P<0.001)。TG/HDL-C是Mets的独立影响因素,在校正相关影响因素后,TG/HDL-C与Mets呈正的关联(比值比=5.23,95%置信区间:3.30-8.29,P<0.001)。结论:TG/HDL-C与2型糖尿病高危人群Mets密切相关,随着TG/HDL-C的升高,Mets的患病风险显著升高。

Objective:To investigate the correlation between triglycerides to high-density lipoprotein cholesterol ratio(TG/HDL-C)and metabolic syndrome(Mets)in high-risk diabetic population.Methods:According to the definition of high-risk groups of type 2 diabetes in China's Guidelines for the Prevention and Treatment of Type 2 Diabetes(2017 Edition),patients were recruited from the outpatient of the Department of Endocrinology of Hebei General Hospital from April 2018 to April 2019.A total of 531 patients participated in the study.A multivariate Logistic regression model was used to assess their correlation between TG/HDL-C and Mets.Results:TG/HDL-C of the patients with Mets was significantly higher than those without Mets[1.73(1.03,2.55)vs 0.76(0.54,1.12),P<0.001].With the increase of TG/HDL-C,the prevalence of Mets gradually increased(P<0.001).TG/HDL-C was an independent influencing factor of Mets.After correcting the relevant influencing factors,TG/HDL-C was positively correlated with Mets(Odds ratios=5.23,95%Confidential interval:3.30-8.29,P<0.001).Conclusion:TG/HDL-C is closely related to Mets in high-risk groups with type 2 diabetes mellitus,and with the increase of TG/HDL-C,the risk of Mets is significantly increased.