摘要
目的探讨单核细胞/高密度脂蛋白胆固醇比值(MHR)、中性粒细胞与单核细胞乘积(NMP)与急性脑梗死病情严重程度的关系。方法选取锦州医科大学附属第三医院2020年9月至2021年9月收治的急性脑梗死患者130例(脑梗死组),另选健康体检者110例(对照组);根据入院时美国卫生研究院卒中量表(NIHSS)评分将脑梗死组分为三个亚组:轻度组63例(NIHSS≤4分);中度组47例(5≤NIHSS≤15分);重度组20例(NIHSS>16分);采用Logistic回归分析确定急性脑梗死的独立危险因素,Spearman相关分析评估脑梗死患者MHR、NMP与NIHSS评分的相关性。结果脑梗死组MHR、NMP明显高于对照组(P<0.05),Logistic回归分析确定MHR、NMP是脑梗死的独立危险因素;不同亚组之间比较,MHR、NMP值依次增高(P<0.05),且与NIHSS评分呈中度正相关(r=0.505、0.471,P<0.05);结论MHR、NMP可作为脑梗死的独立危险因素,MHR、NMP与急性脑梗死患者病情严重程度呈正相关。
【Objective】To explore the relationship between the monocytes/high-density lipoprotein cholesterol ratio(monocyte to high-density lipoprotein cholesterol,MHR),neutrophils and monocytes product(NMP)and acute cerebral infarction disease severity.【Methods】A total of 130 cases of patients with acute cerebral infarction treated in the Third Affiliated Hospital of Jinzhou Medical University from Sep.2020-Sep.2021 were selected(cerebral infarction group).Totally 110 cases underwent physical examination were selected(control group).According the United States institute of Health Stroke Scale(National Institutes of Health Stroke Scale,NIHSS)scores the cerebral infarction group is divided into three subgroups:mild group 63 examples(NIHSS 4 minutes or less);moderate group of 47 cases(5 or less NIHSS 15 points or less);20 cases of severe group(NIHSS>16).Using Logistic regression analysis to identify independent risk factors of ACI,MHR Spearman correlation analysis to evaluate the correlation between MNR,NMP and NIHSS score of cerebral infarction patients.【Results】MHR,NMP of cerebral infarction group was obviously higher than those of control group(P<0.05),Logistic regression analysis confirmed that MHR,NMP was independent risk factors for cerebral infarction.Comparison between different subgroups,MHR,NMP value increased in turn,the difference was statistically significant(P<0.05),and NIHSS score was positively related(correlation coefficient were 0.505,0.471).【Conclusion】MHR,NMP can be regarded as independent risk factors for cerebral infarction,and MHR,NMP were positively correlated with the severity of patients with acute cerebral infarction.
作者
杨诗冬
刘强
YANG Shidong;LIU Qiang(Department of Neurology,the Third Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121000,China)
出处
《中国医学工程》
2022年第10期54-58,共5页
China Medical Engineering