FTO调控PYCR1-RNA-m^(6)A促进膀胱癌发生发展的研究进展

Research progress on FTO regulation of PYCR 1-RNA-m^(6)A to promote the development of bladder cancer

膀胱癌(BLCA)是泌尿生殖系统最常见的恶性肿瘤之一。肥胖相关蛋白(FTO)通过m^(6)A依赖性的去甲基化酶活性广泛参与脂肪形成和肿瘤的发生过程,影响了包括吡咯啉-5-羧酸还原酶(PYCR1)等多个mRNA的转录后修饰,进而导致BLCA的发生发展。本文对FTO调控PYCR1-RNA-m^(6)A促进BLCA发生发展的机制进行详细的总结综述,为后续深入阐明BLCA发生发展的分子机制和临床诊疗提供重要参考。

Bladder cancer(BLCA)is one of the most common urogenital malignancies.Fat mass and obesity-associated protein(FTO)is widely involved in adipogenesis and tumorigenesis through m^(6)A dependent demethylase activity.It affects the post-transcriptional modification of several mRNAs,including PYCR 1,leading to the occurrence and development of BLCA.This paper summarized the regulatory mechanisms of FTO,PYCR 1 and m^(6)A in promoting the occurrence and development of BLCA,providing important reference for further elucidating the molecular mechanism of BLCA occurrence and development and clinical diagnosis and treatment.