肝癌特异性分子标志物glypican-3的研究进展

Research progress of glypican-3,a specific molecular marker for liver cancer

肝细胞癌(hepatocellular carcinoma,HCC)是世界上最常见的癌症之一,死亡率极高,因而HCC的早期诊断十分重要。磷脂酰肌醇蛋白-3(glypican-3,GPC3)的mRNA和蛋白质表达水平在HCC患者体内显著增高,但在正常人和良性肝病患者体内不表达或低水平表达,因此已成为HCC诊断和靶向治疗的特异性生物标志物。本文对GPC3的最新研究进展进行了详细综述,包括其分子结构、生物学功能、在HCC发展过程中的作用、血清学检测方法以及以之为靶点的HCC靶向治疗等。

Hepatocellular carcinoma(HCC)is one of the most common cancers with a very high mortality rate in the world,so early diagnosis of HCC is very important.Glypican-3(GPC3)has significantly increased mRNA and protein expression levels in HCC patients,but is not expressed or expressed at low levels in normal person and patients with benign liver diseases.It has become a specific biomarker for the diagnosis and targeted therapy of HCC.In this paper,we review the latest research progress of GPC3 in detail,including its molecular structure,biological function,role in the development of HCC,serological detection methods as well as the targeted therapy of HCC against it.