保留比例肺功能受损与慢性阻塞性肺疾病的临床探讨

Clinical study on the relationship between the preserved ratio impaired spirometry and chronic obstructive pulmonary disease

保留比例肺功能受损(PRISm)是临床实践中一种常见的肺功能表型,其与第1秒用力呼气容积的加速下降、呼吸道症状、全身性炎症、糖尿病、心血管疾病以及病死率增加等相关。目前对于这种现象产生的机制尚不清楚,部分患者可能是慢性阻塞性肺疾病的早期阶段,重视和早期识别PRISm可能减缓疾病进展,改善生活质量。本文简要讨论了PRISm的临床特征及其与慢性阻塞性肺疾病的相关性。

Preserved ratio impaired spirometry(PRISm),a common lung phenotype in clinical practice,is related to the accelerated decline of forced expiratory volume in one second,respiratory symptoms,systemic inflammation,diabetes,cardiovascular diseases,and increased mortality.The mechanism of this disease remains unclear.Some patients may be in the early stage of chronic obstructive pulmonary disease(COPD).Attention to and early recognition of PRISm may slow dowm the disease progression and improve the quality of life.In this article,we briefly describe the clinical features of PRISm and its correlation with COPD.