直接抗人球蛋白试验阳性患者MAP与生理盐水洗涤红细胞的疗效比较

Efficacy of MAP washing with saline in DAT⁃positive patients

目的探讨MAP洗涤红细胞(MAP washes the red blood cells,Map WBC)及生理盐水混悬洗涤红细胞(normal saline mixed with red blood cells,WBC)对直接抗人球蛋白试验(direct antiglobulin test,DAT)阳性患者输血治疗的疗效分析。方法选择2020年1月至2021年12月本院207例直接抗人球蛋白试验阳性患者,分为MAP组(n=93)和盐水组(n=114),MAP组输注MAP洗涤红细胞治疗,盐水组输注生理盐水混悬洗涤红细胞治疗,通过检测血红蛋白(hemoglobin,HGB)和胆红素(total bilirubin,TBIL)实验室指标观察两组患者的输血疗效,同时对输血不良反应进行观察。结果对两组患者输血前后各指标变化程度进行比较,组内HGB和TBIL明显升高,差异有统计学意义(P<0.05),组间HGB和TBIL变化不明显,差异无统计学意义(P>0.05),且两组输血均无不良反应发生。结论DAT阳性患者输注两种洗涤红细胞均安全有效,但MAP洗涤红细胞由于保存时间长,更能满足临床急诊需求。

Objective To investigate the efficacy of MAP washed red blood cells(MAP WBC)and normal saline mixed with red blood cells(WBC)on direct antiglobulin test(DAT)of blood transfusion therapy in DAT⁃positive patients.Methods From January 2020 to December 2021,207 DAT⁃positive patients in our hospital were selected and divided into MAP group(n=93)and saline group(n=114).MAP group was infused with MAP washed red blood cells for treatment,while saline group was treated by infusion of saline and washed red blood cells mixture.The blood transfusion efficacy as well as side effects of the two groups was observed via detecting the laboratory indexes of hemoglobin(HGB)and total bilirubin(TBIL).Results Comparing the changes of each index before and after blood transfusion in the two groups,inner⁃group HGB and TBIL significantly increased,and the difference was statistically significant(P<0.05),while there was no obvious change in HGB and TBIL between the two groups and the difference was not statistically significant(P>0.05).There were no adverse reactions of blood transfusion in both groups.Conclusion Both types of washed red blood cells are safe and effective for DAT⁃positive patients,but MAP washed red blood cells can better meet the needs of clinical emergency with the capabil⁃ity to be stored for longer period.