细胞外泌体及其内容物在缺血性脑卒中中的研究新进展

Recent advances in the study of exosomes and their contents in ischemic stroke

细胞外泌体能通过传递携带的功能内含物(核糖核酸、蛋白质、脂质体)调控受体细胞功能。在中枢神经系统中,细胞外泌体及其携带的内容物参与维持脑组织微环境稳态及促进脑损伤修复。近年来研究发现脑组织细胞(血管内皮细胞、神经细胞、胶质细胞和干细胞等)外泌体及其携带的内含物通过影响血管和神经功能,以及作为标识物在脑血管疾病尤其是缺血性脑卒中的治疗中发挥重要作用。本综述将阐述细胞外泌体及其携带的内容物在缺血性脑卒中中的研究现状及最新进展,有望为缺血性脑卒中提供新的治疗方案。

Extracellular secretion regulates the function of recipient cells by delivering functional inclusions(RNA,proteins,liposomes)carried by them.In the central nervous system,exosomes and their contents are involved in maintaining the microenvironmental homeostasis of brain tissue and promoting the repair of brain injury.In recent years,studies have found that exosomes of brain tissue cells(vascular endothelial cells,nerve cells,glial cells and stem cells)and their inclusions play an important role in the treatment of cerebrovascular diseases,especially ischemic stroke,by influencing vascular and nerve functions and as markers.This paper will review the research status and latest progress of exosomes and their contents in ischemic stroke,which is expected to provide a new treatment for ischemic stroke.