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小剂量阿司匹林联合硝苯地平、拉贝洛尔治疗妊娠期高血压疾病效果及对血管内皮功能的影响 被引量:1

Effect of low-dose aspirin combined with nifedipine and labetalol in the treatment of gestational hypertension and its effect on vascular endothelial function
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摘要 目的:将小剂量阿司匹林联合硝苯地平、拉贝洛尔用于妊娠期高血压疾病治疗中,评价其效果及对血管内皮功能的影响。方法:选取2019年12月至2021年12月本院收治的192例妊娠期高血压患者,以治疗方案分组,对照组96例应用硝苯地平、拉贝洛尔治疗,观察组96例在此基础上应用小剂量阿司匹林,对两组治疗结果进行比较。结果:观察组总有效率为96.88%,明显较对照组的88.54%高(P<0.05);治疗前,两组内皮素-1(ET-1)、一氧化氮(NO)水平相比无明显差异(P>0.05),治疗后,观察组ET-1水平低于对照组,NO水平高于对照组(P<0.05);治疗前,两组血压水平差异不显著(P>0.05),治疗后,观察组血压水平低于对照组(P<0.05);观察组不良分娩结局发生率为4.17%,较对照组的12.50%低(P<0.05)。结论:小剂量阿司匹林联合硝苯地平、拉贝洛尔在妊娠期高血压疾病中应用价值较高,可降低患者血压水平,改善血管内皮功能及分娩结局,值得应用。 Objective:To investigate the effect of low-dose aspirin combined with nifedipine and labetalol in the treatment of gestational hypertension and its effect on vascular endothelial function.Methods:192 patients with gestational hypertension treated in our hospital from December 2019 to December 2021 were selected,according to the treatment scheme.96 cases in the control group was treated with nifedipine and labetalol.On this basis,96 cases in the observation group was treated with low-dose aspirin,The treatment results of the two groups were compared.Results:The total effective rate in the observation group was 96.88%,which was significantly higher than 88.54% in the control group(P<0.05);Before treatment,there was no significant difference in the levels of endothelin-1(ET-1)and nitric oxide(NO)betwen the two groups(P>0.05).After treatment,the level of ET-1 in the observation group was lower than that in the control group,and the level of NO in the observation group was higher than that in the control group(P<0.05);Before treatment,there was no significant difference in blood pressure between the two groups(P>0.05).After treatment,the blood pressure level of the observation group was lower than that of the control group(P<0.05).The incidence of adverse delivery outcomes in the observation group was 4.17%,which was lower than 12.50% in the control group(P<0.05).Conclusion:The application value of low-dose aspirin combined with nifedipine and labetalol in pregnancy induced hypertension is high.It can reduce the level of blood pressure,improve vascular endothelial function and delivery outcome.It is worth applying.
作者 吴玉环 Wu Yuhuan(Department of Obstetrics,Chengwu People's Hospital of Shandong Province,Heze Shandong,274200,China)
出处 《中外女性健康研究》 2022年第17期63-65,共3页 Women's Health Research
关键词 小剂量阿司匹林 硝苯地平 拉贝洛尔 妊娠期高血压 血管内皮功能 Low dose aspirin Nifedipine Labelor Gestational hypertension Vascular endothelial function
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