单核巨噬细胞系统在心肌损伤和修复中的作用研究进展

Research Progress on the Role of Mononuclear Phagocyte System in Myocardial Injury and Repair

心力衰竭(简称心衰)是各种心血管疾病发展的最后阶段,已成为世界范围内的主要公共卫生问题。慢性心衰的基本病因是各种原因所致的心肌损伤,如心肌梗死、心肌肥厚、心肌炎等,造成心肌结构及功能改变,最终发展为心衰。这些心肌损伤可分为缺血性心肌损伤和非缺血性心肌损伤。越来越多的证据表明,免疫炎症细胞,尤其是单核巨噬细胞,在心肌损伤修复中发挥着重要的作用。本文就单核巨噬细胞在心肌损伤和修复中的作用及其研究进展进行综述。

Heart failure is the last stage of various cardiovascular diseases and has become a major public health problem worldwide.The basic etiology of chronic heart failure is myocardial injury caused by various reasons,such as myocardial infarction,cardiac hypertrophy,myocarditis,etc.,resulting in changes in myocardial structure and function,and eventually develop into heart failure.These myocardial injuries can be classified into ischemic myocardial injuries and non-ischemic myocardial injuries.More and more evidence indicate that immune inflammatory cells,especially mononuclear phagocyte,play an important role in myocardial injury and repair.In this review,we provide the role and research progress of mononuclear phagocyte in myocardial injury and repair.