抗菌肽LL-37研究进展

Research progress in antibacterial peptide LL-37

抗菌肽是一种小分子活性肽,来源广泛,在生物体免疫激活和调节中发挥重要作用,且具有抗菌活性,这为解决抗生素耐药性问题提供了可能。LL-37是组织蛋白酶抑制素家族中唯一在人体内的成员,对革兰阴性菌和革兰阳性菌均有抑制作用。该文从LL-37活性结构域进行分析,阐述了LL-37在抗菌、抗内毒素、创伤愈合、免疫调节等方面的作用机制及临床治疗潜力,展望了其应用前景,为新药研发、食品防腐和动物饲料添加提供思路。

A antimicrobial peptides are small active peptides from a wide range of sources that play an important role in immune activation and regulation of organisms and have antibacterial activity,which can help overcome antibiotic resistance.LL-37 is the only member of the histone protease inhibitor(cathelicidin)family in humans and has inhibitory effects on both Gram-negative and Gram-positive bacteria.This paper analyzes the active structural domain of LL-37,describes the mechanism of action and clinical therapeutic potential of LL-37 in combating bacteria and endotoxin,wound healing and immunomodulation,and predicts its prospect of applications in order to contribute to new drug development,food preservation and animal feed addition.