幽门螺杆菌感染与非酒精性脂肪肝及血脂指标的相关性分析

Correlation between Helicobacter pylori infection and nonalcoholic fatty liver and blood lipid indexes

目的 研究和探讨幽门螺杆菌(helicobacter pylori, HP)感染与非酒精性脂肪肝及血脂指标的相关性。方法 抽取2019年10月—2021年10月时间段内在郑州人民医院行HP检测的患者109例,按照检测结果分为两组,HP阳性组和HP阴性组,例数分别为62例和47例。比较两组中非酒精性脂肪肝及非脂肪肝的占比;对两组血脂指标进行分析,包括:甘油三酯、总胆固醇、高密度脂肪白胆固醇、低密度脂肪白胆固醇、血尿酸、空腹血糖、体重指数。结果 HP阳性组中的非酒精性脂肪肝患者占比高于HP阴性组,(P<0.05);在性别分布方面,HP阳性组中的女性非酒精性脂肪肝占比高于HP阴性组(P<0.05);HP阳性组中的男性非酒精性脂肪肝占比与HP阴性组无差异(P>0.05);两组不同年龄之间非酒精性脂肪肝占比无差异(P>0.05)。HP阳性组中的甘油三酯、血尿酸及体重指数等血脂指标数据均值较HP阴性组高(P<0.05);HP阳性组中的总胆固醇、高密度脂肪白胆固醇、低密度脂肪白胆固醇、空腹血糖均值与HP阴性组无差异(P>0.05)。结论 女性HP感染后较男性更容易引发非酒精性脂肪肝的发生,甘油三酯、血尿酸及体重指数增高与HP感染存在正相关性,HP感染与非酒精性脂肪肝存在密切关联。

Objective To study and explore the correlation between Helicobacter pylori infection(HP) and nonalcoholic fatty liver and blood lipid indexes.Methods Totally 109 patients who underwent HP test in our hospital from October 2019 to October 2021 were selected and divided into two groups according to the test results: HP positive group and HP negative group, with 62 cases and 47 cases respectively.The proportions of nonalcoholic fatty liver and non fatty liver in the two groups were compared;The blood lipid indexes of the two groups were analyzed, including triglyceride, total cholesterol, high-density fat white cholesterol, low-density fat white cholesterol, blood uric acid, fasting blood glucose and body mass index.Results The proportion of patients with nonalcoholic fatty liver in HP positive group was higher than that of HP negative group(P<0.05);In terms of gender distribution, the proportion of female nonalcoholic fatty liver in HP positive group was higher than that of HP negative group(P<0.05);There was no difference in the proportion of male nonalcoholic fatty liver between HP positive group and HP negative group(P>0.05);There was no difference in the proportion of nonalcoholic fatty liver between the two groups at different ages(P>0.05).The mean values of triglyceride, blood uric acid and body mass index in HP positive group were higher than those of HP negative group(P<0.05);The mean values of total cholesterol, high-density fat white cholesterol, low-density fat white cholesterol and fasting blood glucose in HP positive group were not different from those in HP negative group(P>0.05).Conclusion Women are more likely to cause nonalcoholic fatty liver after HP infection than men.The increase of triglyceride, blood uric acid and body mass index are positively correlated with HP infection, and HP infection is closely associated with nonalcoholic fatty liver.