不同精神药物对老年人群按心率校正的QT间期的影响

Effects of different psychotropic drugs on the QTc interval in the elderly population

精神疾病以药物治疗作为主要手段,熟悉精神药物不良反应对治疗方案的制定和优化具有重大意义。按心率校正的QT间期(QTc间期)延长是使用精神药物后最常见的心脏毒性作用之一,其可能引起尖端扭转型室性心动过速并增加心源性猝死风险。老年人群更易出现QTc间期延长。现就老年人群常用精神药物与QTc间期延长的关系及影响因素作一综述,以期能对临床医生在用药选择及规避风险上有所帮助。

Medications are the main means for the treatment of mental illness,and it is of great significance to be familiar with the adverse reactions of psychotropic drugs for the formulation and optimization of treatment plans.The prolongation of the QT interval corrected by heart rate(QTc interval)is one of the most common cardiotoxic reactions after taking psychotropic drugs and may lead to torsade de pointes and increase the risk of sudden cardiac death.The elderly population is more prone to QTc interval prolongation.In this review,we focus on the relationship between common psychotropic drugs and QTc interval prolongation and influencing factors in the elderly population,so as to help clinicians avoid risk in drug selection.