分子即时检测(POCT)技术及其在新发传染病中的应用

Molecular Diagnostic POCT Technology and Its Application in Emerging Infectious Diseases

分子即时检测(point-of-care testing,POCT)技术具有灵敏度高、分析速度快、体积小、检测成本低廉等特点,在分子诊断领域受到广泛关注。近年来,分子POCT技术的发展与应用在应对新发、突发传染病,保护人类生命健康方面具有重大意义。介绍近五年来新兴的分子POCT技术,总结新兴分子POCT技术的最新研究进展及应用前景,分析POCT技术的优势与面临的挑战,探讨提高其检测灵敏度和选择性的技术策略。

The development and application of molecular point-of-care(POCT) technology has been noticed in recent years because of its high sensitivity, fast analysis speed, small size, and low detection cost. The development and application of molecular POCT technology is of great significance for protecting human life and health and coping with the threat of emerging and sudden infectious diseases. In this paper, several emerging molecular POCT technologies in the past five years, focusing on describing the latest research progress, and their application prospects were introduced. The advantages and challenges of molecular POCT were discussed, as well as the technical strategies to improve its detection sensitivity and selectivity.