致女性乳腺脓肿的棒状杆菌种类及药敏谱分析

Analysis of species and antibiotic sensitivity of Corynebacterium in female breast abscess

目的调查引起女性乳腺脓肿的棒状杆菌种类及其药敏谱,辅助临床诊断和治疗。方法检测2017年1月-2022年3月疑似女性乳腺脓肿的脓液样本,生长有疑似棒状杆菌的革兰阳性杆菌经MALDI-TOF VITEK MS系统鉴定,同时进行药敏试验。结果从17例女性乳腺脓肿患者中分离到棒状杆菌,其中16例为C.kroppenstedtii,1例为C.tuberculostearicum。药敏结果显示,这2种棒状杆菌对利奈唑胺和万古霉素基本全敏感,对美洛培南敏感性较高。结论棒状杆菌是引起女性乳腺脓肿的主要病原菌之一,不同种类的棒状杆菌药敏谱存在一定差异,因此菌种鉴定和药敏试验非常重要。

Objective To investigate the species and antibiotic sensitivity of Corynebacterium causing female breast abscess in order to assist clinical diagnosis and treatment.Methods The pus samples of suspected female breast abscess from January2017 to March 2022 were detected.The Gram-positive bacilli with suspected Corynebacterium was identified by MALDI-TOF VITEK MS system,and the antibiotic sensitivity test was carried out at the same time.Results In 17 strains of Corynebacterium isolated from female patients with breast abscess,16 isolates were C.kroppenstedtii and 1 isolate was C.tuberculostearicum.The results of antibiotic sensitivity showed that the two strains of Corynebacterium were completely sensitive to linezolid and vancomycin and highly sensitive to meropenem.Conclusion Corynebacterium is one of the main pathogens causing female breast abscess.There are some differences in the antibiotic spectrum of different kinds of Corynebacterium.Therefore,strain identification and antibiotic susceptibility test are significant.