广东孕期妇女弓形虫IgG抗体定量截断值设置探讨

Discussion on the cutoff value of toxoplasma IgG quantitation among peri-conception women in Guangdong province of China

目的探讨广东地区孕期妇女弓形虫(TOX)IgG抗体定量截断值的科学设置,为临床判读弓形虫血清抗体结果,指导孕前孕期保健工作提供准确依据。方法选取2020年在该院作孕前和孕期TOX-IgG检测筛查者血清为5144份,采用罗氏电化学发光法定量检测TOX-IgG。按定量值从低到高做累积百分数分布图。参考文献报道不同地区TOX-IgG的阳性率数据,选择最符合广东地区的阳性率区间,并据此设置对应截断值。结果广东地区育龄妇女TOX-IgG阳性率合理区间为8.55%~10.54%,对应的TOX-IgG截断值为10~18 IU/mL。结论本研究获得的广东孕期妇女TOX-IgG抗体定量截断值较为符合本地区流行情况,据此可更准确判读TOX-IgG抗体的阴阳性,以便临床对孕期妇女进行弓形虫感染风险评估及相应诊疗指导。

Objective To evaluate the appropriate Cut off value in the toxoplasma(TOX)IgG quantitation test among peri-conception women in Guangdong,P.R.China.Thus provides reasonable judgement of positive/negative result of a TOX-IgG quantitation test and,in turn,guidance for peri-conceptional Toxoplasmosis relevant management.Methods A total of 5144 sera from peri-conception women who sought for TORCH screening in Guangdong provincial women and children,s hospital during 2020 were included.Tox-IgG quantitation was done by Roche electrochemiluminescence method.According to the ascending of TOX-IgG quantitative value,a cumulative percentage distribution chart of specimens numbers was made.Literature reports of population TOX-IgG positive rate in different regions were extensively reviewed.The positive rate interval that best fitted the Guangdong population was selected.Then the corresponding Cut off value was set accordingly on our cumulative percentage distribution char.Results The positive rate of TOX-IgG in women of childbearing age in Guangdong was 8.55%-10.54%.And the corresponding cutoff values interval was 10-18 IU/mL.Conclusion The TOX-IgG cutoff values interval among peri-conceptional women set by our study was rationally consistent with the epidemiological situation in Guangdong,P.R.China.It will facilitate the accurate discrimination of a negative or positive result in TOX-IgG quantitation test.So that it can aid the practitioners in peri-conceptional toxoplasma relevant counselling and management.