尿BTA、NMP22联合尿脱落细胞学检查对尿路上皮癌诊断的价值分析

Exploration of the combined diagnostic value of tumor markers BTA,NMP22 and urine cytology in bladder cancer

目的通过对膀胱肿瘤相关抗原(BTA)、核基质蛋白22(NMP22)及尿脱落细胞形态检查,判断其在尿路上皮癌诊断中的灵敏度及特异度,以评价其联合检测的诊断价值。方法收集该院泌尿外科病例278例(其中试验组138例,对照组140例)尿液标本,定量测定BTA、定性测定NMP22及尿脱落细胞学检查。分析其联合检测的灵敏度及特异度。结果联合检测的灵敏度和特异度分别为7.29%,93.31%。结论尿脱落细胞学、BTA、NMP22联合检,可提高尿路上皮癌早期诊断的灵敏度、特异度,对尿路上皮癌的早期诊断、预后及复发的诊疗具有重要的意义。

Objective To evaluate the diagnostic value of bladder tumor-associated antigens BTA,nuclear matrix protein 22(NMP22)and urine exfoliative cytology in the diagnosis of bladder urothelial carcinoma.Methods Collectied 278 urine sample(including 140 from normal control group and 138 from tumor patients)in Taihe hospital.The BTA,qualitative NMP22 and urine exfoliative cytology in urine samples were quantitatively determined by different assays.Results The sensitivity and specificity of the combined detection were 7.29%and 93.31%,respectively.Conclusion The combination of urinary exfoliative cytology and tumor-associated markers BTA and NMP22 have a promising future in early diagnosis of bladder cancer.