膀胱癌患者来源的异种移植物模型构建与应用研究进展

Research progress in the construction and application of xenograft model from patients with bladder cancer

肿瘤患者来源的异种移植物模型可将肿瘤组织植入免疫缺陷小鼠体内,以保留患者肿瘤的组织学和分子表型特征,进一步再现原发肿瘤的异质性,因此,该模型成为较为可靠的体内人类肿瘤模型,能更加精准地用于开发特定肿瘤生物标志物、创建个体化治疗以及研发治疗癌症的药物。本文就目前有关膀胱癌患者来源的异种移植物模型构建过程中受体动物的选择、移植部位以及该模型的优势与不足等相关研究进展进行综述,以期为其应用于膀胱癌治疗的研究提供参考依据。

The tumor patient-derived xenograft model allows the implantation of tumor tissue into immunodeficient mice to preserve the histological and molecular phenotypic characteristics of tumor and further recapitulate the heterogeneity of the primary tumor.Therefore,this model has become a more reliable human tumor model in vivo,which can be used more precisely for developing specific tumor biomarkers,creating individualized therapies,and developing drugs to treat cancer.This article reviews the current research on the selection of recipient animals,transplantation sites,and the advantages,disadvantages of the xenograft model derived from patients with bladder cancer,so as to provide a reference for the study of its application in the treatment of bladder cancer.