一氧化碳在肾脏疾病中的作用

Roles of carbon monoxide in kidney disease

一氧化碳(carbon monoxide,CO)是一种由血红素加氧酶(heme oxygenase,HO)催化血红素降解产生的内源性气体信号分子。近年来研究表明,低浓度CO具有抗炎、抗氧化、抑制凋亡、舒张血管等作用,并在缺血再灌注性肾损伤、脓毒症相关急性肾损伤、中毒性肾病和糖尿病肾脏疾病等肾脏疾病中有保护作用。本文回溯了CO在肾脏生理和病理生理中的作用及机制,就CO对肾脏疾病发病机制的影响进行综述。

Carbon monoxide(CO)is an endogenous gas signaling molecule released through a degradation of heme in the presence of heme oxygenase(HO).Recent studies have demonstrated that a low concentration of CO had diverse effects of anti-inflammatory,anti-oxidant,anti-apoptotic and vaso⁃dilation.Thus it played protective roles in renal diseases through mediating ischemia-reperfusion renal in⁃jury,sepsis-related acute kidney injury,toxic nephropathy and diabetic nephropathy.This review sum⁃marized the roles and mechanisms of CO in kidney pathophysiology and examined the impacts of CO on the pathogenesis of kidney diseases.