浓缩生长因子在活髓保存治疗中的应用前景

Prospects for the application of concentrated growth factor in vital pulp therapy

活髓保存治疗是牙髓损伤的微创治疗手段,盖髓材料的不断优化对其疗效起重要作用。研究表明,生物陶瓷类材料负载生物活性小分子物质进行活髓保存治疗可诱导牙髓牙本质复合体生成。浓缩生长因子(CGF)属第3代自体血小板浓缩物,富含白细胞及大量生物活性因子,在活髓保存治疗中存在广阔的应用前景。本文对CGF的发展历程、制备方法及活性成分进行归纳,并将其应用于组织修复再生的相关研究进行综述,为CGF在活髓保存治疗的应用提供思路和研究方向。

Vital pulp therapy(VPT)is a minimally invasive treatment for pulp injury,and the continuous optimization of pulp capping materials plays an important role in its curative effect.Studies have shown that bio ceramic materials loaded with biologically active small molecules for VPT can induce dental pulp-dentin complexes.Concentrated growth factor(CGF)is a third-generation autologous platelet concentrate,rich in white blood cells and a large number of biologically active factors,and has broad application prospects in VPT.This article summarizes the development,preparation methods,and active ingredients of CGF,and reviews the related research on its application in tissue repair and regeneration,which can provide new ideas for the research of CGF in VPT.