肝细胞癌动物模型的研究进展

Research progress on animal model of hepatocellular carcinoma

目的 总结近年来国内外关于肝细胞癌(简称肝癌)动物模型的应用研究进展。方法 查阅近年来国内外有关肝癌动物模型的相关文献并进行综述。结果 目前常见的肝癌动物模型主要有自发型动物模型、诱发型动物模型、基因修饰型动物模型、移植型动物模型和人源化动物模型5种,各种动物模型的病因、发病机制以及病理生理学变化各不相同,肝癌动物模型的选择具体取决于研究的类型及目的。结论 各种肝癌动物模型各有其优缺点,研究者应根据自身研究目的选择不同的动物模型,以达到预期实验目的,从而使更多肝癌动物模型有价值的研究成果应用于临床,最终这些研究成果能被真正运用于肝癌的诊断以及治疗。

Objective To summarize the application research progress of animal models of hepatocellular carcinoma at home and abroad in recent years. Method The relevant literature on animal models of hepatocellular carcinoma at home and abroad in recent years was reviewed. Results At present, the common animal models of hepatocellular carcinoma mainly included spontaneous animal model, induced animal model, gene modified animal model, transplanted animal model, and humanized animal model. The etiology, pathogenesis, and pathophysiological changes of various animal models were different. The selection of animal models of hepatocellular carcinoma depended on the type and purpose of research. Conclusions Various animal models of hepatocellular carcinoma have their own advantages and disadvantages. Researchers should choose different animal models according to their own research purposes to achieve the expected experimental purposes, so that more valuable research results of animal models of hepatocellular carcinoma can be applied to clinical practice, and finally these research results can be truly applied to diagnosis and treatment of hepatocellular carcinoma.