健康青年血清Irisin水平与高甘油三酯腰围表型的相关研究

CORRELATION BETWEEN SERUM IRISIN LEVEL AND HYPERTRIGLYCERIDEMIC-WAIST PHENOTYPE IN HEALTHY YOUNG PEOPLE

目的 探讨健康青年血清鸢尾素(Irisin)水平与高甘油三酯腰围(HTGW)表型的关系。方法 采用横断面研究方法选取334例20~45岁健康体检青年,以甘油三酯及腰围分组,甘油三酯、腰围均正常者为对照组;高甘油三酯或高腰围者为单项组;高甘油三酯腰围表型(HTGW)者为病例组。比较三 组 间 年 龄、性别、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、腰围(WC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)、Irisin水平。结果 男性高 HTGW 表型比例高于女性,病例组BMI、WC、SBP、DBP、FPG、LgINS、TG水平高于其他二组,单项组高于对照组,组间比较差异有统计学意义(P<0.05);而病例组 HDL-C、Irisin水平低于其他二组,单项组低于对照组,差异有统计学意义(P<0.05)。以血清irisin水平中位数分组,irisin水平低于中位数组的高甘油三酯腰围表型发生率高于高水平组,差异有统计学意义 (χ^(2)=40.13,P=0.003)(OR=5.294,95%CI=2.889~9.700;OR=4.615,95%CI=2.641~8.066)。校正性别、年龄进行多因素 Logistic回归,Irisin与 HTGW 表型独立相关(OR=0.724,P<0.05)。结论 青年男性存在代谢异常比例高于女性,健康青年血清Irisin水平与 HTGW 表型有关,高Irisin水平是HTWG表型的独立保护因素。

Objective To investigate the correlation between serum irisin level and hypertriglyceridemic-waist(HTGW) phenotype in healthy young people.Methods Across-sectional study was conducted to observe three hundred and thirty-four healthy young people aged 20~45 years.They were divided into three groups: the control group with normal triglyceride(TG)and waist circumference(WC),the single group with high TG or WC,the case group with high TG and WC(HTGW).Age, sex, systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),WC,TG,high density lipoprotein-cholesterol(HDL-C),fasting blood glucose(FPG),fasting insulin(FINS)and irisin were compared among three groups.Results The proportion of HTGW phenotype in male was significantly higher than that in female.The levels of BMI,WC,SBP,DBP,FPG,LgINS and TG in the case group were higher than those in the other two groups, and those in the single group were higher than those in control group, the differences were statistically significant(P<0.05).The levels of HDL-C and irisin in case group were lower than those in the other two groups, and those in the single group were lower than those in control group, the differences were statistically significant(P<0.05).The incidence of high triglyceride waist circumference phenotype with irisin level lower than median array was higher than that in high level group, the difference was statistically significant(χ^(2)=40.13,P=0.003)(OR=5.294,95%CI=2.889~9.700;OR=4.615,95%CI=2.64~ 8.066).After adjustment for sex, age, multivariate logistic regression analysis showed that irisin was independently correlated with HTGW phenotype(OR=0.724,P<0.05).Conclusion The proportion of metabolic abnormalities in healthy young men is significantly higher than in women.The serum level of irisin is correlated with HTGW phenotype in healthy young people.The increase of serum irisin level is expected to be a protective factor to reduce the occurrence ofHTGW phenotype.