复方氨基丁酸维E胶囊联合拉莫三嗪对小儿癫痫患者血清GFAP、HMGB1水平的影响

EFFECT OF COMPOUND AMINOBUTYRIC ACID VITAMIN E CAPSULE COMBINED WITH LAMOTRIGINE ON SERUM GFAP AND HMGB1 LEVELS IN CHILDREN WITH EPILEPSY

目的 探讨复方氨基丁酸维E胶囊联合拉莫三嗪对小儿癫痫患者血清神经胶质纤维酸性蛋白(GFAP)、高迁移率族蛋白1(HMGB1)水平的影响。方法 选取2020年1—12月该院收治的160例癫痫患儿,随机将其分为各80例的对照组与观察组。对照组采用拉莫三嗪治疗,观察组联合复方氨基丁酸维E胶囊治疗。评估二组临床治疗效果和用药安全性。比较二组患儿癫痫发作情况。比较二组患儿GFAP和HMGB1水平。结果 观察组患者治疗总体有效率较对照组显著增加(P<0.05)。二组治疗后癫痫发作持续时间和发作频率显著低于治疗前(P<0.05),观察组治疗后癫痫发作情况显著优于对照组(P<0.05)。二组治疗后GFAP和HMGB1水平显著低于治疗前(P<0.05),观察组治疗后GFAP和HMGB1显著低于对照组(P<0.05)。二组不良反应发生率比较无统计学意义(P>0.05)。结论 复方氨基丁酸维E胶囊联合拉莫三嗪可有效提高癫痫患儿临床疗效,降低血清GFAP、HMGB1水平,减少癫痫发作频率,缩短癫痫发作持续时间,且不良反应发生率低。

Objective To investigate the effect of compound aminobutyric acid vitamin E capsule combined with lamotrigine on the levels of serum Glial fibrillary acid protein(GFAP) and High mobility group box 1 protein(HMGB1) in children with epilepsy.Methods A total of one hundred and sixty children with epilepsy treated in our hospital from January 2020 to December 2020 were randomly divided into control group and treatment group.The control group was treated with lamotrigine, and the observation group was treated with compound aminobutyric acid vitamin E capsule.The clinical therapeutic effect and drug safety of the two groups were evaluated.Epileptic seizures were compared between the two groups.The levels of GFAP and HMGB1 were compared between the two groups.Results The overall effective rate of the observation group was significantly higher than that of the control group(P<0.05).The duration and frequency of seizures in the two groups after treatment were significantly lower than those before treatment(P<0.05),and the seizures in the observation group were significantly better than those in the control group(P<0.05).The levels of GFAP and HMGB1 in the two groups after treatment were significantly lower than those before treatment(P<0.05),the levels of GFAP and HMGB1 in the observation group were significantly lower than those in the control group(P<0.05).There was no statistical significance in the incidence of adverse reactions between two groups(P>0.05).Conclusion Compound aminobutyric acid vitamin E capsule combined with lamotrigine can effectively improve the clinical efficacy of children with epilepsy, reduce the levels of serum GFAP and HMGB1,reduce the frequency of seizures, shorten the duration of seizures, and the incidence of adverse reactions is low.