低剂量芬吗通联合坤泰胶囊治疗围绝经期综合征的疗效

Curative Effect of Low Dose Femoston Combined with Kuntai Capsule on Perimenopausal Syndrome

目的研究低剂量芬吗通联合坤泰胶囊治疗围绝经期综合征的疗效。方法选取2019年6月-2021年8月我院接受治疗的围绝经期综合征患者60例,按照随机数字表法分为研究组和对照组,每组30例。对照组给予常规剂量芬吗通治疗,研究组给予低剂量芬吗通联合坤泰胶囊治疗,比较两组临床疗效、性激素水平、不良反应发生情况及心理状态。结果研究组治疗有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05);两组治疗后E2水平高于治疗前,LH、FSH水平低于治疗前,且研究组E2水平高于对照组,LH、FSH水平低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P<0.05);两组治疗后抑郁评分和焦虑评分低于治疗前,但研究组低于对照组,差异有统计学意义(P<0.05)。结论低剂量芬吗通联合坤泰胶囊治疗围绝经期综合征的效果良好,有利于改善性激素水平,缓解不良情绪,降低不良反应发生率,具有应用安全性。

Objective To study the efficacy of low-dose femoston combined with Kuntai capsule in the treatment of perimenopausal syndrome.Methods Sixty female patients with perimenopausal syndrome who were treated in our hospital from June 2019 to August 2021 were selected and divided into study group and control group according to the random number table method,with 30 cases in each group.The control group was treated with routine dose of femoston,and the study group was treated with low dose of femoston combined with Kuntai capsule.The clinical efficacy,sex hormone levels,adverse reactions and psychological status were compared between the two groups.Results The effective rate of treatment in the study group was 96.67%,which was higher than 73.33%in the control group,the difference was statistically significant(P<0.05).After treatment,the levels of E2 in the two groups were higher than those before treatment,the levels of LH and FSH were lower than those before treatment,and the levels of E2 in the study group were higher than those in the control group,the levels of LH and FSH were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).The depression score and anxiety score of the two groups after treatment were lower than those before treatment,but the study group was lower than the control group,the difference was statistically significant(P<0.05).Conclusion Low-dose femoston combined with kuntai capsule has a good effect in the treatment of perimenopausal syndrome,which is beneficial to improve the level of sex hormones,mood,reducing the incidence of adverse reactions,and has application safety.