TCT和HPV在HSIL及宫颈癌患者中的应用分析

Application of TCT and HPV in HSIL and Cervical Cancer Patients

目的研究宫颈液基细胞学检测(TCT)及人乳头状瘤病毒(HPV)检测在高级别鳞状上皮内病变(HSIL)及宫颈癌早期筛查中的临床意义。方法选取2020年3月-2021年8月空军军医大学第一附属医院经病理诊断为HSIL和宫颈癌的268例患者作为研究对象,均行HPV、TCT及宫颈组织活检,以病理诊断为金标准,对TCT及HPV检测结果进行分析。结果268例患者中病理诊断为HSIL共238例,宫颈鳞癌28例,宫颈腺癌2例。268例患者中TCT检查结果阳性率为89.93%,以HSIL为主,其次是LSIL;5例患者TCT结果为AGC,但是病理结果均为HSIL,而2例腺癌患者TCT结果为ASCUS。HPV检测结果阳性率为96.64%,阳性率从高到低前6种亚型为HPV16、58、52、18、33、31。结论TCT与HPV在检测HSIL及宫颈癌中均具有重要作用,开展早期联合筛查可减少HSIL和宫颈癌的漏诊率。

Objective To study the clinical significance of thinprep cytologic test(TCT)and human papillomavirus(HPV)detection in early screening of high-grade squamous intraepithelial lesion(HSIL)and cervical cancer.Methods A total of 268 patients who were pathologically diagnosed as HSIL and cervical cancer in the First Affiliated Hospital of Air Force Medical University from March 2020 to August 2021 were selected as the study subjects.All patients underwent HPV,TCT and cervical biopsy.TCT and HPV test results were analyzed with pathological diagnosis as the gold standard.Results Of the 268 patients,238 were pathologically diagnosed as HSIL,28 were cervical squamous cell carcinoma,and 2 were cervical adenocarcinoma.The positive rate of TCT in 268 patients was 89.93%,mainly HSIL,followed by LSIL;TCT results of 5 patients were AGC,but the pathological results were HSIL,while TCT results of 2 patients with adenocarcinoma were ASCUS.The positive rate of HPV test results was 96.64%,and the positive rate from high to low was HPV16,58,52,18,33,31.Conclusion TCT and HPV play an important role in the detection of HSIL and cervical cancer.Early combined screening can reduce the missed diagnosis rate of HSIL and cervical cancer.