miR-21促进肺癌进展相关机制及潜在治疗靶点

Related mechanisms and potential therapeutic targets of Mir-21 in promoting lung cancer progression

肺癌是严重威胁人类生命健康的疾病之一,目前其发病率和死亡率居所有癌症之首。microRNA-21(miR-21)作为一种致癌的miRNA(oncomiR),在多种实体瘤中的表达显著增加。miR-21在非小细胞肺癌(NSCLC)中可以通过改变各种靶分子的表达来调节癌细胞的增殖、侵袭、凋亡,降低遗传稳定性。本文系统性地综述了miR-21在NSCLC中的表达及其调控作用,从基因的表达、临床诊断、治疗与预后等方面探讨了miR-21在NSCLC发生发展中的作用、相关临床应用及潜在的应用价值。

Lung cancer is one of the diseases that seriously threaten human life and health.At present,its morbidity and mortality rank first among all cancers.As an oncogenic miRNA(oncomiR),the expression of microrNA-21(Mir-21)is significantly increased in a variety of solid tumors.In non-small cell lung cancer(NSCLC),Mir-21 can regulate the proliferation,invasion and apoptosis of cancer cells and reduce genetic stability by changing the expression of various target molecules.This paper systematically reviewed the expression and regulatory role of Mir-21 in NSCLC,and discussed the role of Mir-21 in the occurrence and development of NSCLC,related clinical application and potential application value from the aspects of gene expression,clinical diagnosis,treatment and prognosis.