盐酸纳布啡与丙泊酚对无痛支气管镜检查期间躁动呛咳的影响

Effect of nalbuphine hydrochloride and propofol on restlessness and choking during painless bronchoscopy

目的:分析盐酸纳布啡与丙泊酚在无痛支气管镜检查中的应用价值。方法:选取2020年6月至2020年10月在绵阳市中心医院接受无痛支气管镜检查的60例患者,按随机数表法分成研究组、对照1组和对照2组,每组20例。在检查期间,研究组给予盐酸纳布啡+丙泊酚,对照1组给予单纯盐酸纳布啡,对照2组给予单纯丙泊酚。观察各组的心率、平均动脉压和全麻苏醒期躁动呛咳的发生率及严重性。结果:研究组呛咳的出现情况及严重性均显著优于对照1、2组(P<0.05)。研究组躁动的出现情况及严重性均显著优于对照1、2组(P<0.05)。研究组拔管时及拔管后1 min的平均动脉压及心率均显著低于对照1、2组(P<0.05)。结论:盐酸纳布啡+丙泊酚能减少全麻苏醒期躁动及呛咳的出现,抑制气管拔管相关的血流动力学改变。

Objective:To analyze the application value of nalbuphine hydrochloride and propofol in painless bronchoscopy.Methods:A total of 60 patients who underwent painless bronchoscopy in Mianyang Central Hospital from June 2020 to October 2020 were selected and divided into study group,control group 1 and control group 2 according to the random number table method,with 20 cases in each group.During the examination period,the study group was given nalbuphine hydrochloride plus propofol,the control group 1 was given nalbuphine hydrochloride alone,and the control group 2 was given propofol alone.The heart rate,mean arterial pressure,incidence and severity of restless cough during recovery from general anesthesia were observed in each group.Results:The occurrence and severity of cough in the study group were significantly better than those in the control groups 1 and 2(P<0.05).The occurrence and severity of agitation in the study group were significantly better than those in the control groups 1 and 2(P<0.05).The mean arterial pressure and heart rate at extubation and 1 min after extubation in the study group were significantly lower than those in the control groups 1 and 2(P<0.05).Conclusion:Nalbuphine hydrochloride+propofol can reduce agitation and cough during recovery from general anesthesia,and inhibit hemodynamic changes related to tracheal extubation.