基于数据挖掘技术探析中医治疗原发性肝癌的用药规律

Exploring the medication rule of TCM on primary liver cancer based on data mining technology

目的:挖掘分析现代中医治疗原发性肝癌的组方规律,以期为临床诊疗用药以及药物研发提供一定的依据。方法:以中国知识资源总库中近三十年来中医治疗原发性肝癌的临床经验文献作为数据来源,通过数据筛选构建数据库,通过中医传承计算平台V3.0进行分析。结果:按照纳入与排除标准筛选出65篇文献,共纳入88首方剂,涉及中药208味;所涉及的药物四气以温、寒、平为主;五味以苦、甘、辛为主;归经以脾、肝、肺三经为主;药物功效以补虚类、活血化瘀类为主;药物组合中频次为20及20以上者有17组;聚类分析发现核心药物组合有3个。结论:中医在治疗原发性肝癌时主要以“补虚培本,清热活血,利水渗湿”展开,经过分析后得出的数据组合有一定的指导借鉴意义,但仍需与中医理论相结合,进行进一步临床以及实验验证。

Objective:To explore and analyze the prescription rules of modern TCM in the treatment of primary liver cancer,in order to provide a certain basis for clinical diagnosis,treatment and drug development.Methods:The clinical experience literature of TCM treatment of primary liver cancer in the past 30 years in CNKI was used as data sources,and the database was constructed through data screening.The results were analyzed by TCMICSV3.0.Results:A total of 65 studies were screened out according to exclusion criteria,including 88 prescriptions,involving 208 TCM medicines.After analysis,it was found that the four Qi(气)were mainly warm,cold and flat.The five flavors are mainly bitter,sweet and acrid.The main channels are spleen,liver and lung meridians.The efficacy of drugs was mainly tonifying deficiency,promoting blood circulation and removing stasis.There were 17 groups of drug combinations with a frequency of 20 and above;cluster analysis found that there were 3 core drug combinations.Conclusion:TCM mainly focuses on“tonifying deficiency,promoting blood circulation,and diuretic dampness”in the treatment of primary liver cancer.The data combination obtained after analysis has a certain guiding significance,but it still needs to be combined with the theory of TCM for further clinical and experimental verification.