平衡化湿汤联合莫沙必利对脾虚气滞证消化不良患者的疗效、不良情绪及复发的影响

The effect,adverse emotion and palindromia of the Pingheng Huashi decoction plus mosapride on dyspepsia patients with spleen deficiency and Qi stagnation syndrome

目的:研究平衡化湿汤联合莫沙必利对脾虚气滞证消化不良患者的疗效、不良情绪及复发的影响。希望为临床中西医联合治疗脾虚气滞证消化不良患者提供参考。方法:选取2017年6月-2019年5月在内蒙古包钢医院收治的消化不良患者120例,根据患者意愿将其分为对照组(55例)和研究组(65例)。对照组行莫沙必利治疗,研究组在对照组西药治疗基础上联合平衡化湿汤治疗。观察两组患者临床疗效、不良情绪、中医证候积分、复发率、胃肠激素水平、不良反应率。结果:研究组患者临床疗效高于对照组(P<0.05);治疗后,研究组患者中医证候积分低于对照组,有显著差异(P<0.05);治疗后,两组患者GAS、SS低于治疗前(P<0.05),胃动素(Motilin,MTL)高于治疗前(P<0.05);治疗后,研究组患者胃泌素(Gastrin,GAS)、生长抑素(Somatostatin,SS)低于对照组(P<0.05),MTL高于对照组(P<0.05);治疗后,研究组患者焦虑、抑郁、恐惧、敌对、偏执、强迫症、精神病性、躯体化、人际交往、总不良情绪低于对照组(P<0.05);研究组复发率低于对照组(P<0.05);研究组总不良反应率低于对照组(P<0.05)。结论:平衡化湿汤联合莫沙必利治疗脾虚气滞证消化不良患者,能够提高临床疗效,减少复发率,缓解患者不良情绪,且不良反应较少。

Objective:To study the effect of the Pingheng Huashi decoction(平衡化湿汤)and mosapride on dyspepsia patients with spleen deficiency and Qi stagnation(脾虚气滞证).It is hoped to provide a reference for treating the disease in the integrative medicine.Methods:A total of 120 dyspepsia patients from May 2017 to May 2019 were selected and divided into the control group(55 cases)and the study group(65 cases)according to the patients’wishes.The control group was treated with mosorride,and the study group was treated with the Pingheng Huashi decoction more.Clinical efficacy,adverse mood,TCM syndrome score,recurrence rate,gastrointestinal hormone level,and adverse reaction rate were observed in both groups.Results:The efficacy rate in the study group was higher than the control group(P<0.05).The TCM syndrome score in the study group was lower than the control group,with a significant difference(P<0.05).Post-treatment,GAS and SS in groups were lower than before treatment(P<0.05),and MTL was higher than before treatment(P<0.05);The GAS and SS in the study group were lower than those in the control group(P<0.05),MTL was higher than the control group(P<0.05).Post-treatment,the rates of anxiety,depression,fear,hostility,paranoia,obsessive-compulsive disorder,psychosis,somatization,interpersonal communication,and total bad mood in the study group were lower than the control group(P<0.05).The recurrence rate in the study group was lower than the control group(P<0.05).The adverse reaction rate in the study group was lower than that in the control group(P<0.05).Conclusion:The Pingheng Huashi decoction plus mosapride can improve clinical efficacy,reduce recurrence rate,and relieve bad mood,with less adverse reactions.