多烯磷脂酰胆碱与异甘草酸镁治疗脂肪肝的效果和患者不良反应评价

Efficacy of Polyene Phosphatidylcholine and Magnesium Isoglycyrrhizinate in the Treatment of Fatty Liver and Evaluation of Adverse Reactions in Patients

目的探究多烯磷脂酰胆碱与异甘草酸镁治疗脂肪肝患者的效果及不良反应。方法2018年9月—2020年9月,方便选取盐城市第三人民医院收治的102例脂肪肝患者,按照随机数法将患者分为对照组和观察组,每组51例,分别应用多烯磷脂酰胆碱、异甘草酸镁进行治疗。治疗结束后对比两组患者的临床疗效和肝功能情况。结果观察组患者治疗有效率为98.04%,高于对照组84.31%,对比差异有统计学意义(χ^(2)=4.387,P=0.036);治疗前两组肝功能指标对比,差异无统计学意义(P>0.05);治疗后对比,观察组肝功能指标优于对照组,差异有统计学意义(P<0.05);观察组和对照组的不良反应发生率分别为1.96%、3.92%,对比差异无统计学意义(χ^(2)=0.000,P>0.05)。结论异甘草酸镁更大程度地改善肝功能各指标,临床疗效更加明显,不良反应少。

Objective To explore the efficacy and adverse reactions of polyene phosphatidylcholine and magnesium isoglycyrrhizinate in the treatment of patients with fatty liver.Methods From September 2018 to September 2020,Conveniently Selected 102 patients with fatty liver admitted to the Third People´s Hospital of Yancheng City were included and divided into control group and observation group according to random number method.Each group of 51 patients was treated with polyene phosphatidylcholine and magnesium isoglycyrrhizinate respectively.After the treatment,the clinical efficacy and liver function of the two groups were compared.Results Compared with the effective rate of treatment,the observation group was 98.04%,which was higher than that of the control group(84.31%),and the difference was statistically significant(χ^(2)=4.387,P=0.036).There was no statistically significant difference in liver function indexes before treatmen(P>0.05).The liver function indexes in observation after treatment were better than that of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group and the control group were 1.96%and 3.92%,and there was no statistically significant difference(P>0.05).Conclusion Magnesium isoglycyrrhizinate can improve various indicators of liver function to a greater extent,with more obvious clinical efficacy and less adverse reactions.