海洋生物碱Manzamine A的全合成研究进展

Research Progress on Total Synthesis of Marine Alkaloid of Manzamine A

目的 为海洋天然产物生物碱Manzamine A的全合成研究提供参考。方法 检索相关文献,对已报道的5篇Manzamine A的全合成文献进行要点阐述,提炼合成路线的特点。结果 针对Manzamine A的全合成,已报道有不少新颖的合成方法,但总体较烦琐,合成效率不高,不利于更深入地开展生物活性的研究。结论 该类天然产物因其结构复杂,合成难度大,有待发掘更多新颖的合成方法和策略。

Objective To provide a reference for the total synthesis of marine natural alkaloid of Manzamine A.Methods Five related studies were searched,and the main points of the total synthesis of Manzamine A were elaborated to extract the characteristics of the synthetic routes.Results Many novel synthesis methods had been reported for the total synthesis of Manzamine A,but generally cumbersome and inefficient,which were not able to facilitate the further research on the biological activity of Manzamine A.Conclusion Due to the complex structure and difficult synthesis,more novel synthesis methods and strategies of such natural products need to be explored.