静息态功能磁共振成像在局灶性肌张力障碍中的应用研究进展

Research progress in resting state functional magnetic resonance imaging of brain in focal dystonia

肌张力障碍是以异常动作和姿势为特征的一类运动障碍疾病,严重影响患者的社交及生活质量。目前对该病早期干预的定位判断、疗效分析及预后评估等存在一定困难。静息态功能磁共振成像(rs-fMRI)是一种先进的测量静息状态下脑部自发神经活动的技术,由于其具有无创、简便易行、分析方法多样等优势而广泛应用于肌张力障碍的相关研究。研究发现,肌张力障碍不单纯是基底神经节功能障碍,而是一种神经网络障碍性疾病。本文简述rs-fMRI的工作原理、临床应用,重点阐明其在各种局灶性肌张力障碍中的应用研究进展,以期为研发更有效的治疗药物提供功能影像学依据。

Dystonia is a type of movement disorder disease characterized by abnormal movements and postures,which seriously affects patients’ social life and quality of life.However,there are certain difficulties in positioning judgment of early intervention,efficacy analysis and prognostic evaluation at present.Resting state functional magnetic resonance imaging (rs-fMRI) is an advanced technique for measuring the brain’s spontaneous nerve activity at rest.It is widely used in the study of dystonia due to its advantages of non-invasiveness,simplicity and ease of use,and diverse analysis methods.Studies have shown that dystonia is not simply a basal ganglia dysfunction,but a neural network disorder.This article briefly describes the principle and clinical application of rs-fMRI,focusing on the research progress of rs-fMRI in various dystonia diseases,which will help to further understand the pathogenesis of focal dystonia to provide functional imaging basis for the development of more effective therapeutic drugs.