sdLDL-C、Annexin A2、Hcy对AIS患者颈动脉斑块稳定性的评估价值

The evaluation value of sdLDL-C,Annexin A2 and Hcy in the assessment of carotid plaque stability in patients with AIS

目的 探究小而密低密度脂蛋白胆固醇(sdLDL-C)、膜联蛋白A2(Annexin A2)、同型半胱氨酸(Hcy)对急性缺血性脑卒中(AIS)患者颈动脉斑块稳定性的评估价值。方法 选取2019年8月至2022年2月期间河北北方学院附属第二医院AIS患者92例为研究对象,根据颈动脉斑块的影像学检查结果分为稳定斑块组(n=33)与不稳定斑块组(n=59),另选取同期30名健康体检者为健康组。检测并对比3组患者血清sdLDL-C、Annexin A2、Hcy水平,并绘制ROC曲线分析上述指标对AIS患者颈动脉斑块稳定性的评估价值。结果 sdLDL-C、Annexin A2、Hcy水平:不稳定性斑块组>稳定性斑块组>健康组,差异具有统计学意义(F=179.585、23.468、66.324,P<0.05);多因素Logistic回归分析显示,sdLDL-C(OR=3.212)、Annexin A2(OR=2.522)、Hcy(OR=8.750)是AIS患者颈动脉斑块稳定性的独立影响因素(P<0.05)。ROC曲线分析显示,Hcy、sdLDL-C、Annexin A2对应的AUC分别为0.862、0.837、0.795,判断AIS患者颈动脉斑块稳定性的敏感度、特异度分别为86.4%、84.8%;83.1%、81.8%;79.7%、81.8%。结论 检测sdLDL-C、Annexin A2、Hcy对AIS患者颈动脉斑块稳定性的判断具有重要价值。

Objective To investigate the effect of small dense Low-Density Lipoprotein(sdLDLC),Annexin A2 and homocysteine(Hcy)on carotid plaques in patients with acute ischemic stroke(AIS)evaluation. Methods A total of 92 patients with AIS in the Second Affiliated Hospital of Hebei Northern University from August 2019 to February 2022 were selected as the research subjects. According to the imaging results of carotid plaques,they were divided into stable plaque group(n=33)and unstable plaque group(n=59). Another 30 healthy subjects were selected as the healthy group during the same period. The serum levels of sdLDL-C,Annexin A2 and Hcy in the three groups were detected and compared,and the ROC curve was drawn to analyze the evaluation value of the above indicators for carotid plaque stability in patients with AIS.Results The levels of sdLDL-C,Annexin A2 and Hcy:unstable plaque group > stable plaque group > healthy group,the difference was statistically significant(F=179.585、23.468、66.324,P<0.05). Multivariate Logistic regression analysis showed that sdLDL-C(OR=3.212),Annexin A2(OR=2.522),and Hcy(OR=8.750)were independent influencing factors of carotid plaque stability in AIS patients(P<0.05). ROC curve analysis showed that the AUCs corresponding to Hcy,sdLDL-C and Annexin A2 were 0.862,0.837 and 0.795,respectively,and the sensitivity and specificity for judging the stability of carotid plaque in patients with AIS were 86.4% and 84.8%;81.8%;79.7%,81.8%. Conclusion The detection of sdLDL-C,Annexin A2 and Hcy is of great value in judging the stability of carotid plaques in patients with AIS.