山慈菇的化学成分及其抗肿瘤作用机制研究进展

RESEARCH PROGRESS ON CHEMICAL CONSTITUENTS AND ANTI-TUMOR MECHANISM OF PSEUDOBULBUS CREMASTRAE SEU PLEIONES

山慈菇,味甘、微辛,归肝、脾经。研究表明,山慈菇的主要化学成分包括菲类化合物、联苄类化合物、芳香化合物及其苷类、糖及糖苷类化合物、萜类及甾体类化合物、黄酮类化合物等,具有抗菌、降压、治疗痛风、抗肿瘤以及阻断乙酰胆碱受体M3等作用。近年来,山慈菇由于良好的抗肿瘤活性,而在临床上被广泛应用。其抗癌机制涉及抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤新生血管生成、抑制肿瘤细胞的侵袭和转移、增强机体免疫力等。本文将对山慈菇的化学成分及其抗肿瘤作用机制作一综述,以期为山慈菇的抗肿瘤机制及深入开发研究提供理论支持。

Cichorium edulis is the dry pseudobulb of Cremastra appendiculata(D.Don)Makino,Pleione bulbocodioides(Franch.)Rolfe,Pleione yunnanensis Rolfe. Studies have shown that the main chemical components of Cichorium edulis are phenanthrene compounds, bibenzyl compounds, aromatic compounds and their glycosides, sugars and glycoside compounds,terpenoids and steroids, flavonoids, etc. Cichorium edulis has antibacterial, antihypertensive, treatment of gout, anti-tumor and blocking acetylcholine receptor M3 and so on. In recent years, Cichorium edulis has been widely used in the clinical treatment of tumors due to its good anti-tumor activity. Its anticancer mechanism involves inhibiting tumor cell proliferation,inducing tumor cell apoptosis, inhibiting tumor angiogenesis, inhibiting tumor cell invasion and metastasis, and enhancing body immunity. The paper will make a review of the chemical constituents and anti-tumor mechanism of Cichorium edulis, in order to provide theoretical support for the anti-tumor mechanism and in-depth development research of Cichorium edulis.