NICU肠道病毒感染高危因素及临床特点

Risk factors and clinical characteristics of enterovirus infection in NICU

目的 探讨新生儿重症监护室(NICU)肠道病毒感染的高危因素及临床特点。方法 收集2020年10月-2021年10月出生后72 h内入住石河子大学医学院第一附属医院NICU的162例新生儿为研究对象,收集粪便标本,采用RT-PCR检测肠道病毒RNA,了解石河子地区新生儿肠道病毒感染高峰季节,分析新生儿肠道病毒感染的高危因素及临床表现。结果 石河子地区新生儿肠道病毒感染高峰季节为6~10月,肠道病毒感染组和非肠道病毒感染组在胎龄、性别、出生体重、分娩方式、胎膜早破、发热、呼吸道症状、神经系统症状及黄疸发生率方面差异无统计学意义(P>0.05),2组在消化道症状发生率方面有统计学差异(P<0.05)。结论 在肠道病毒流行季节,需警惕肠道病毒感染,严格执行消毒隔离制度,防止其在医院内暴发流行。

Objective To investigate the high risk factors and clinical characteristics of enterovirus infection in NICU,the First Affiliated Hospital of Shihezi University Medical College.Methods A total of 162 newborns admitted to NICU of the First Affiliated Hospital of Shihezi University School of Medicine within 72 hours after birth from October 2020 to October 2021were collected as the study subjects. Stool tables were collected and enterovirus RNA was detected by RT-PCR to understand the peak season of enterovirus infection among newborns in Shihezi area. To analyze the risk factors and clinical manifestations of enterovirus infection in neonates. Results Neonatal enterovirus infection shihezi peak season for 6-in October,enterovirus infection group and no enterovirus infection in gestational age,sex,birth weight,childbirth way,premature rupture of membranes,fever,respiratory symptoms,nervous system symptoms and no statistically significant difference in incidence of jaundice,two groups has statistical difference in the incidence of gastrointestinal symptoms. Conclusion In the epidemic season of Enterovirus,it is necessary to be alert to enterovirus infection and strictly enforce the system of disinfection and isolation in order to prevent the outbreak of enterovirus infection in hospitals.