摘要
[Objectives]To explore the role and molecular mechanisms of aerobic exercise in post-stroke depression.[Methods]Wistar rats were randomly divided into sham,sedentary and aerobic exercise(Ex)groups.The rats in sedentary and Ex groups received middle cerebral artery occlusion(MCAO)surgery.Aerobic exercise was performed 24 h after MCAO for four weeks in Ex group.The sucrose preference test(SPT),open field test(OFT),tail suspension test(TST)was performed,respectively.The levels of IL-1β,IL-6,TNF-αwere detected by ELISA.[Results]Aerobic exercise successfully prevented depression-like symptom induced by ischemic stroke with sedentary behavior as indicated by significant increase in sucrose preference(P<0.01)during SPT and decrease in immobility time(P<0.01)during FST and TST.Aerobic exercise significantly reduced the high levels of IL-1β,IL-6,TNF-αinduced by ischemic stroke and sedentary behavior in the ischemic hippocampus(P<0.05).[Conclusions]Aerobic exercise after ischemic stroke can reverse depression and improve the inflammatory microenvironment in the hippocampus.
