雷公藤甲素脂质体粉雾剂的处方工艺筛选与评价

Screening and Evaluation of Formulation Technology of Friptolide Liposome Powder Spray

为降低雷公藤甲素的毒副作用,制备雷公藤甲素脂质体粉雾剂(TP-LD),并进行初步评价。方法采用乙醇注入法和冷冻干燥法制备雷公藤甲素脂质体粉雾剂,并对其进行处方工艺的研究和制剂学评价。结果 雷公藤甲素脂质体包封率为(74.6±1.7)%,粒径大小为(113.03±2.4) nm;Zeta电位为(-43.60±1.2) mv;冻干复溶后TP-LD的粒径大小为(1.17±0.047)μm,流动性与亲水性均较好,满足粉雾剂给药的基本要求。结论 成功制备雷公藤甲素脂质体粉雾剂,工艺简单可行、质量稳定。

Triptolide liposome powder spray(TP-LD) was prepared and evaluated it in order to reduce the toxic and side effects of triptolide.Triptolide liposome powder was prepared by ethanol injection method and freeze-drying method, and its formulation technology was studied and evaluated.Results showed that the entrapment efficiency of triptolide liposomes was(74.6±1.7)%,the particle size was(113.03± 2.4) nm, and the zeta potential was(-43.60±1.2) MV. After freeze-drying, the particle size of the powder spray was(1.17±0.047)μm and the fluidity and hydrophilicity were good, which met the basic requirements of powder spray administration. Triptolide liposome powder spray was successfully prepared with simple and feasible process and stable quality.