血清维生素D水平与老年2型糖尿病患者合并认知障碍的关系研究

Study on The Relationship Between Serum Vitamin D Levels and Cognitive Impairment in Elderly Patients with Type 2 Diabetes Mellitus

目的:探讨血清维生素D水平与老年2型糖尿病患者合并认知障碍的关系。方法:收集2021年1月-2022年1月在我院就诊的90例老年糖尿病患者为研究对象。收集老年人性别、年龄、受教育年限、吸烟史、饮酒史、身高、体重、体育活动情况等一般信息及实验室血清25羟维生素D_(3)[25(OH)D_(3)]水平检测数据。采用简易智力状态检查(MMSE)量表对患者认知状况进行评估,将患者分为认知正常组和轻度认知障碍组(MCI),分析血清维生素D水平与MCI间的关系。结果:90例老年2型糖尿病患者中,28例发生MCI,发生率为31.11%。男性血清25(OH)D_(3)水平为(25.82±6.32)ng/mL,维生素D缺乏率合计为15.21%;女性血清25(OH)D_(3)水平为(24.09±7.92)ng/mL,维生素D缺乏率合计为18.18%,女性血清25(OH)D_(3)水平显著低于男性(P<0.05)。血清维生素D水平与患者MMSE得分之间呈正相关,年龄、性别、体重过轻、空腹血糖过高、HbA1c过高、血清维生素D水平低是老年糖尿病患者发生MCI的独立危险因素。结论:血清维生素D水平低与老年2型糖尿病患者合并MCI密切相关,适当补充维生素D可能对老年2型糖尿病患者发生认知衰退具有保护作用。

【Objective】 To explore the relationship between serum vitamin D levels and cognitive impairment in elderly patients with type 2 diabetes mellitus.【Method】 Totally 90 elderly patients with diabetes mellitus attending our hospital from January 2021 to January 2022 were collected for the study.General information such as gender,age,years of education,history of smoking,history of alcohol consumption,height,weight,physical activity and laboratory data of serum 25 hydroxyvitamin D 3[25(OH)D 3]level test were collected from the elderly.The Mini-mental State Examination(MMSE)scale was used to assess the cognitive status of the patients,and the patients were divided into normal cognitive group and mild cognitive impairment(MCI)group to analyze the relationship between serum vitamin D levels and MCI.【Result】 MCI occurred in 28 of 90 elderly patients with type 2 diabetes,with an incidence of 31.11%.Serum 25(OH)D 3 levels were(25.82±6.32)ng/mL in men,with a vitamin D deficiency rate of 15.21%.Serum 25(OH)D 3 levels were(24.09±7.92)ng/mL in women,with a vitamin D deficiency rate of 18.18%,and serum 25(OH)D 3 levels were significantly lower in women than in men(P<0.05).There was a positive correlation between serum vitamin D levels and MMSE scores.Age,gender,underweight,high fasting glucose,high HbA1c,and low serum vitamin D levels were independent risk factors for the development of MCI in elderly diabetic patients.【Conclusion】 Low serum vitamin D levels are strongly associated with MCI in elderly patients with type 2 diabetes,and appropriate vitamin D supplementation may have a protective effect against the development of cognitive decline in elderly patients with type 2 diabetes.