MoS_(2)/Fe_(3)O_(4)/Au复合材料制备及多功能生物探针

Preparation of MoS_(2)/Fe_(3)O_(4)/Au Composites and Multifunctional Biological Probes

采用拉曼光谱分析复合前后样品的拉曼特性,发现引入Fe_(3)O_(4)纳米粒子后MoS_(2)的E^(1)_(2g)和A_(1g)拉曼振动峰红移,进一步引入Au纳米粒子后拉曼散射强度得到有效增强。磁学性质分析表明MoS_(2)/Fe_(3)O_(4)/Au复合材料无剩磁、无矫顽力,具有超顺磁性。复合材料与人IgG分子偶联后样品的傅里叶变换红外(FTIR)光谱中可以观察到酰胺键及-S-S-键等生物基团,表明可基于该复合材料构建生物探针。对比实验表明,生物分子偶联未影响复合材料拉曼光谱,且此生物探针在1.2 T磁场强度下1 min内即可富集。因此,该多功能材料可作为各类病原体的早期快速诊断的候选材料。

Raman spectroscopy was used to analyze the Raman characteristics of the samples before and after recombination.After compounding Fe_(3)O_(4) nanoparticles,t he E^(1)_(2g) and A_(1g) peak positions of MoS_(2) shifted red,and the Raman peak intensity was effectively enhanced after compounding Au.The analysis of magnetic properties shows that MoS_(2)/Fe_(3)O_(4)/Au composites have no remanence,coercivity and super-paramagnetic.After the composite was coupled with human IgG molecule,biological groups such as amide bond and-S-S-bond could be observed in the Fourier transform infrared(FTIR)spectrum of the samples.It shows that the biological probes can be constructed based on the composite.Comparative experiments show that bio-molecular coupling does not affect the Raman spectra of the composites,and the biological probes can be enriched within 1 min under the magnetic field intensity of 1.2 T.Therefore,t he multifunctional material can be used as a candidate material for early,r apid and diagnosis of various pathogens.