血清白细胞介素-27水平与慢性乙型肝炎患者肝纤维化的关系

Relationship between serum interleukin-27 level and liver fibrosis in patients with chronic hepatitis B

目的探讨慢性乙型肝炎患者血清白细胞介素-27(IL-27)水平与肝纤维化分期的关系。方法选取100例慢性乙型肝炎患者作为研究对象,患者均行肝穿刺活检。根据病理分期结果,将100例患者分别纳入S1期组、S2期组、S3期组、S4期组。设计基线资料调查表,详细统计并比较各组患者的基线资料;分析血清IL-27水平与慢性乙型肝炎患者肝纤维化的关系。结果100例慢性乙型肝炎患者的病理分期结果为S1期47例、S2期29例、S3期15例、S4期9例;S1期组、S2期组、S3期组、S4期组患者血小板(PLT)水平依次下降,丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、IL-27水平依次升高,差异有统计学意义(P<0.05);4组慢性乙型肝炎患者其他资料比较,差异无统计学意义(P>0.05)。Kendall′s tau-b相关性分析发现,慢性乙型肝炎患者肝纤维化分期与血清IL-27水平呈正相关(r=0.577,P<0.001);多项Logistic回归分析结果显示,血清IL-27水平过高表达分别是慢性乙型肝炎患者肝纤维化S2期、S3期、S4期的危险因素(OR>1,P<0.05)。结论血清IL-27水平异常表达可能与慢性乙型肝炎患者肝纤维化分期有关。

Objective To investigate the relationship between serum interleukin-27(IL-27)level and liver fibrosis stage in patients with chronic hepatitis B.Methods A total of 100 patients with chronic hepatitis B were selected as research subjects,all patients underwent liver biopsy.According to the pathological staging results,these patients were divided into S1 stage group,S2 stage group,S3 stage group and S4 stage group.The baseline data questionnaire was designed by the researcher,and the baseline data of patients were compared in detail,the relationship between serum IL-27 level and liver fibrosis in patients with chronic hepatitis B was analyzed.Results A total of 100 patients with chronic hepatitis B were evaluated by pathological stage.There were 47 cases in S1 stage,29 cases in S2 stage,15 cases in S3 stage and 9 cases in S4 stage.The platelet count(PLT)level of patients with chronic hepatitis B in the S1 stage group,S2 stage group,S3 group and S4 group showed a decreased trend,and the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and IL-27 showed increased trend(P<0.05).There were no statistically significant differences in other data of patients with chronic hepatitis B(P>0.05).According to Kendall′s tau-b correlation analysis,there was a positive correlation between the stage of liver fibrosis and the level of serum IL-27 in patients with chronic hepatitis B(r=0.577,P<0.001);multiple Logistic regression analysis showed that overexpression of serum IL-27 level was a risk factor of liver fibrosis in S2,S3 and S4 stages in patients with chronic hepatitis B(OR>1,P<0.05).Conclusion The abnormal expression of serum IL-27 may be related to the stage of liver fibrosis in patients with chronic hepatitis B.